(αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide

Base Information

Chemical Name:(αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide
CAS No.:219872-85-2
Molecular Formula:C13H14F2N4O2
Molecular Weight:296.277
Hs Code.:
Mol file:219872-85-2.mol

Synonyms:(αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide

Suppliers and Price of (αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
(αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-methyl-1H-1,2,4-triazole-1-butanamide
25 mg
$ 2120.00

Total 2 raw suppliers

Chemical Property of (αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide

Chemical Property:

PSA：95.02000
LogP:1.71520
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

(αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-methyl-1H-1,2,4-triazole-1-butanamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide can be used in the preparation of triazole antifungal agents.

Technology Process of (αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide

There total 5 articles about (αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 170862-36-9
(2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile

: 219872-85-2
(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanamide

Guidance literature:: With dihydrogen peroxide; sodium carbonate; In water; acetone; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2008.10.055

Reference yield:

: 166948-49-8
(2R,3R)-3-[3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-3-(1H-1,2,4-triazol-1-yl)]butanoic acid

: 219872-85-2
(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanamide

Guidance literature:: (2R,3R)-3-[3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-3-(1H-1,2,4-triazol-1-yl)]butanoic acid; With thionyl chloride; In tetrahydrofuran; at 35 - 40 ℃;

With ammonia; at 5 - 10 ℃; for 2h; Reagent/catalyst; Solvent; Temperature;

Reference yield:

: 86404-63-9
1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

: 219872-85-2
(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloro-trimethyl-silane; zinc; iodine / tetrahydrofuran / 16 h / 50 °C / Inert atmosphere; Reflux

2.1: sodium hydroxide; water / methanol / 25 - 35 °C

3.1: (S)-1-phenyl-ethylamine / ethyl acetate; isopropyl alcohol / 0.5 h / 75 - 80 °C

3.2: pH > 10

4.1: thionyl chloride / tetrahydrofuran / 35 - 40 °C

4.2: 2 h / 5 - 10 °C

With chloro-trimethyl-silane; thionyl chloride; (S)-1-phenyl-ethylamine; water; iodine; sodium hydroxide; zinc; In tetrahydrofuran; methanol; ethyl acetate; isopropyl alcohol;