Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate

Base Information

• Chemical Name: Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate
• CAS No.: 1408168-76-2
• Molecular Formula: C7H11BF3KO2-
• Molecular Weight: 236.0814296
• Hs Code.: 2931900090
• Mol file: 1408168-76-2.mol

Synonyms:Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate

Chemical Property of Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate

Chemical Property:

• PSA: 18.46000
• LogP: -4.58890
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98.5% ^*data from raw suppliers

Potassium 2-(tetrahydro-2h-pyran-2-yloxy)ethyltrifluoroborate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate

There total 3 articles about Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

potassium hydrogenfluoride (1279123-63-5) + 4,4,5,5-tetramethyl-2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)-1,3,2-dioxaborolane → potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate (1408168-76-2)

Guidance literature:

With water; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

Reference yield: 74.0%

potassium hydrogen difluoride + 4,4,5,5-tetramethyl-2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)-1,3,2-dioxaborolane → potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate (1408168-76-2)

Guidance literature:

In tetrahydrofuran; water; at 20 ℃; for 2h;

Reference yield:

2-(2-bromoethoxy)tetrahydropyran (17739-45-6,59146-56-4) → potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate (1408168-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; lithium methanolate / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

2: water; tetrahydrofuran / 2 h / 20 °C

With copper(l) iodide; lithium methanolate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1021/jo3021665

upstream raw materials:

2-(2-bromoethoxy)tetrahydropyran

potassium hydrogenfluoride

Downstream raw materials:

2-(4-methoxyphenethoxy)tetrahydro-2H-pyran

Refernces

• 1、 -. "6,7,8,9-TETRAHYDRO-5H-PYRIDO[2,3-d]AZEPINE DOPAMINE D3 LIGANDS". . . Retrieved 2017/08/30.