3,4-Pyrrolidinediol, 2-[(phosphonooxy)methyl]-, (2R,3R,4S)- (9CI)

Base Information

Chemical Name:3,4-Pyrrolidinediol, 2-[(phosphonooxy)methyl]-, (2R,3R,4S)- (9CI)
CAS No.:208658-24-6
Molecular Formula:C₅H₁₂NO₆P
Molecular Weight:213.127
Hs Code.:
Mol file:208658-24-6.mol

Synonyms:3,4-Pyrrolidinediol, 2-[(phosphonooxy)methyl]-, (2R,3R,4S)- (9CI)

Suppliers and Price of 3,4-Pyrrolidinediol, 2-[(phosphonooxy)methyl]-, (2R,3R,4S)- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,4-Pyrrolidinediol, 2-[(phosphonooxy)methyl]-, (2R,3R,4S)- (9CI)

Chemical Property:

Boiling Point:490.2±55.0 °C(Predicted)
PKA:1.78±0.10(Predicted)
Density:1.700±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:

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Technology Process of 3,4-Pyrrolidinediol, 2-[(phosphonooxy)methyl]-, (2R,3R,4S)- (9CI)

There total 3 articles about 3,4-Pyrrolidinediol, 2-[(phosphonooxy)methyl]-, (2R,3R,4S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 148252-71-5
(2R,3R,4S)-1-(benzyloxycarbonyl)-2-<(phosphooxy)methyl>pyrrolidine-3,4-diol

: 208658-24-6
(2R,3R,4S)-2-[(phosphooxy)methyl]pyrrolidine-3,4-diol

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; water; for 4h; under 2585.74 Torr;
DOI:10.1021/jm020541u

Reference yield:

: 111265-96-4
(2R,3R,4S)-1-(benzyloxycarbonyl)-2-(hydroxymethyl)pyrrolidine-3,4-diol 3,4-O-isopropylidene acetal

: 208658-24-6
(2R,3R,4S)-2-[(phosphooxy)methyl]pyrrolidine-3,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1: POCl₃; pyridine; H₂O / acetonitrile / 2 h / 4 °C

2: 0.51 g / aq. HCl / acetonitrile / 0.75 h / 20 °C

3: 100 percent / H₂ / Pd/C / methanol; H₂O / 4 h / 2585.74 Torr

With pyridine; hydrogenchloride; water; hydrogen; trichlorophosphate; palladium on activated charcoal; In methanol; water; acetonitrile;
DOI:10.1021/jm020541u

Reference yield:

: 1053262-99-9
(3aR,4R,6aS)-2,2-Dimethyl-4-phosphonooxymethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid benzyl ester

: 208658-24-6
(2R,3R,4S)-2-[(phosphooxy)methyl]pyrrolidine-3,4-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 0.51 g / aq. HCl / acetonitrile / 0.75 h / 20 °C

2: 100 percent / H₂ / Pd/C / methanol; H₂O / 4 h / 2585.74 Torr

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water; acetonitrile;
DOI:10.1021/jm020541u