Dabigatran Impurity p

Base Information

Chemical Name:Dabigatran Impurity p
CAS No.:1408238-37-8
Molecular Formula:C32H36N6O6
Molecular Weight:600.674
Hs Code.:
Mol file:1408238-37-8.mol

Synonyms:3-(2-(((4-(((hexyloxy)carbonyl)carbamoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoic acid

Suppliers and Price of Dabigatran Impurity p

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]carbonyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine
250mg
$ 3865.00

TRC
N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]carbonyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine
50mg
$ 880.00

Total 16 raw suppliers

Chemical Property of Dabigatran Impurity p

Chemical Property:

PKA:4.17±0.10(Predicted)
PSA：155.75000
Density:1.29±0.1 g/cm3(Predicted)
LogP:5.61250
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

97% ^*data from raw suppliers

N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]carbonyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]carbonyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine is an impurity of Dabigatran Etexilate Mesylate (D100150) which is a nonpeptide, direct thrombin inhibitor.

Technology Process of Dabigatran Impurity p

There total 6 articles about Dabigatran Impurity p which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.5%

: 1415506-19-2,212321-78-3
3-[[[2-[[[4-[amino[[[(hexyloxy)carbonyl]amino]methyl]]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid

: 1408238-37-8
3-(2-(((4-(((hexyloxy)carbonyl)carbamoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propionic acid

Guidance literature:: With hydrogenchloride; water; In acetonitrile; at 40 ℃; Solvent; Reagent/catalyst; Temperature;

Reference yield:

: 211915-06-9
dabigatran etexilate

: 1408238-37-8
3-(2-(((4-(((hexyloxy)carbonyl)carbamoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propionic acid

Guidance literature:: With methanesulfonic acid; water; at 55 ℃; for 168h;

Reference yield:

: 42288-26-6
(4-cyanophenyl)glycine

: 1408238-37-8
3-(2-(((4-(((hexyloxy)carbonyl)carbamoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / Reflux

1.2: Reflux

1.3: 0.5 h / 40 °C

2.1: hydrogenchloride; toluene-4-sulfonic acid / ethanol / 48 h / 20 °C

2.2: 10 - 20 °C

3.1: potassium carbonate / water; tetrahydrofuran / 1.25 h / 20 °C

4.1: water; methanesulfonic acid / 168 h / 55 °C

With hydrogenchloride; methanesulfonic acid; water; potassium carbonate; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; water;