(2R, 4R)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL

Base Information

• Chemical Name: (2R, 4R)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL
• CAS No.: 164267-53-2
• Molecular Formula: C₅H₁₀O₃
• Molecular Weight: 118.133
• Mol file: 164267-53-2.mol

Synonyms:(2R, 4R)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL;(3R,5R)-5-(hydroxyMethyl)tetrahydrofuran-3-ol

Chemical Property of (2R, 4R)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL

Chemical Property:

• PSA: 49.69000
• LogP: -0.87150
• Storage Temp.: 2-8°C

Purity/Quality:

≥95% ^*data from raw suppliers

(3R,5R)-5-(Hydroxymethyl)tetrahydrofuran-3-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R, 4R)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL

There total 20 articles about (2R, 4R)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(3R,5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)tetrahydrofuran-3-ol (936251-85-3) → (3R,5S)-5-(hydroxymethyl)tetrahydrofuran-3-ol (164267-53-2,164267-54-3,204509-08-0,259539-06-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tet.2007.04.047

Reference yield: 80.0%

(3S,5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)tetrahydrofuran-3-ol (936251-84-2) → (3S,5S)-5-(hydroxymethyl)tetrahydrofuran-3-ol (164267-53-2,164267-54-3,204509-08-0,259539-06-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tet.2007.04.047

Reference yield: 78.0%

(2S,4S)-1,2:4,5-dianhydro-3-deoxypentitol (109905-51-3) → (3S,5R)-5-(hydroxymethyl)tetrahydrofuran-3-ol (204509-32-0,164267-53-2,164267-54-3,204509-08-0,259539-06-5)

Guidance literature:

With sodium hydroxide; at 0 - 25 ℃; for 36h;

DOI:10.1021/jo9721655

upstream raw materials:

1,4-pentadiene diepoxide

sulfuric acid

(2S,4S)-1,2:4,5-dianhydro-3-deoxypentitol

1,4-Pentadiene