Technology Process of 6-Bromo-2-methoxynicotinaldehyde
There total 5 articles about 6-Bromo-2-methoxynicotinaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-bromo-3-iodo-2-methoxypyridine;
With
n-butyllithium;
In
diethyl ether;
at -80 ℃;
for 1h;
Inert atmosphere;
N,N-dimethyl-formamide;
In
diethyl ether;
at -80 ℃;
for 1h;
Inert atmosphere;
With
water;
In
diethyl ether;
at -80 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / -30 °C
2.1: hydrogenchloride; sodium nitrite / water / 0.33 h / 5 °C
2.2: 5 - 60 °C
3.1: n-butyllithium / diethyl ether / 1 h / -80 °C / Inert atmosphere
3.2: 1 h / -80 °C / Inert atmosphere
3.3: -80 °C
With
hydrogenchloride; N-Bromosuccinimide; n-butyllithium; sodium nitrite;
In
diethyl ether; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / palladium 10% on activated carbon / methanol / 4 h
2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / -30 °C
3.1: hydrogenchloride; sodium nitrite / water / 0.33 h / 5 °C
3.2: 5 - 60 °C
4.1: n-butyllithium / diethyl ether / 1 h / -80 °C / Inert atmosphere
4.2: 1 h / -80 °C / Inert atmosphere
4.3: -80 °C
With
hydrogenchloride; N-Bromosuccinimide; n-butyllithium; hydrogen; sodium nitrite;
palladium 10% on activated carbon;
In
methanol; diethyl ether; water; N,N-dimethyl-formamide;
