(+)-Bicifadine Hydrochloride

Base Information

• Chemical Name: (+)-Bicifadine Hydrochloride
• CAS No.: 66504-82-3
• Molecular Formula: C12H16ClN
• Molecular Weight: 209.719
• Mol file: 66504-82-3.mol

Synonyms:(1R,5S)-1-(4-Methylphenyl)-

Chemical Property of (+)-Bicifadine Hydrochloride

Chemical Property:

• PSA: 12.03000
• LogP: 2.98670

Purity/Quality:

95% ^*data from raw suppliers

(+)-BicifadineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+)-Bicifadine Hydrochloride

There total 4 articles about (+)-Bicifadine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(1R,5S)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane (83213-66-5) → (1R,5S)-1-(4-methylphenyl)-3-azabicyclo<3.1.0>hexane hydrochloride (66504-82-3)

Guidance literature:

With hydrogenchloride; In ethyl acetate; isopropyl alcohol; at 20 ℃; Product distribution / selectivity;

Reference yield: 66.0%

(1R,2S)-2-(benzyloxymethyl)-1-p-tolylcyclopropanecarbonitrile → (1R,5S)-1-(4-methylphenyl)-3-azabicyclo<3.1.0>hexane hydrochloride (66504-82-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 175 ℃; Inert atmosphere; Microwave irradiation;

DOI:10.1021/jo302443k

Reference yield:

C11H14ClN → (1R,5S)-1-(4-methylphenyl)-3-azabicyclo<3.1.0>hexane hydrochloride (66504-82-3)

Guidance literature:

C₁₁H₁₄ClN; With sodium hydroxide; In Isopropyl acetate; water; at 30 ℃; for 3 - 5h; pH=8.5 - 9.0;

With hydrogenchloride; In Isopropyl acetate; water; at 30 ℃;

upstream raw materials:

(1R,5S)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane

(4-methylphenyl)acetonitrile

Refernces

• 1、 -. "PROCESS FOR THE SYNTHESIS OF (+) AND (-)-1-ARYL-3-AZABICYCLO[3.1.0]HEXANES". Page/Page column 10-11; 14-15. . Retrieved 2008/06/13.