Technology Process of ethyl 4-methyl-3-(4-(methylsulfinyl)thieno[3,2-d]pyrimidine-7-carboxamido)benzoate
There total 4 articles about ethyl 4-methyl-3-(4-(methylsulfinyl)thieno[3,2-d]pyrimidine-7-carboxamido)benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 4-methyl-3-(4-(methylthio)thieno[3,2-d]pyrimidine-7-carboxamido)benzoate;
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 - 20 ℃;
With
sodium hydrogencarbonate;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; dimethyl sulfoxide; acetone / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 45 °C
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
With
sodium chlorite; sodium dihydrogenphosphate dihydrate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU;
In
dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ozone / chloroform; methanol / 0.5 h / -78 °C
2: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; dimethyl sulfoxide; acetone / 0 - 20 °C
3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 45 °C
4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
With
sodium chlorite; sodium dihydrogenphosphate dihydrate; ozone; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU;
In
methanol; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;