(2R)-2-(3-CHLOROPHENYL)PYRROLIDINE

Base Information

• Chemical Name: (2R)-2-(3-CHLOROPHENYL)PYRROLIDINE
• CAS No.: 1217756-62-1
• Molecular Formula: C10H12ClN
• Molecular Weight: 181.66198
• Mol file: 1217756-62-1.mol

Synonyms:(2R)-2-(3-CHLOROPHENYL)PYRROLIDINE;(2R)-2-(3-CHLOROPHENYL)PYRROLIDINE-HCL

Chemical Property of (2R)-2-(3-CHLOROPHENYL)PYRROLIDINE

Chemical Property:

• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

(R)-2-(3-Chloro-phenyl)-pyrrolidine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-(3-CHLOROPHENYL)PYRROLIDINE

There total 19 articles about (2R)-2-(3-CHLOROPHENYL)PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C10H10ClN*H(1+) → (+)-2-(3-chlorophenyl)pyrrolidine (1217756-62-1)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R,R)-f-spiroPhos; hydrogen; In tetrahydrofuran; at 30 ℃; for 10h; under 7600.51 Torr; enantioselective reaction; Autoclave;

DOI:10.1021/acs.orglett.7b01828

Reference yield: 60.3%

5-(3-chlorophenyl)-3,4-dihydro-2H-pyrrole (374588-99-5) → (2R)-2-(3-chlorophenyl)pyrrolidine (1217756-62-1)

Guidance literature:

With hydrogenchloride; 2,3,4,5,6-pentahydroxy-hexanal; nicotinamide adenine dinucleotide phosphate; In aq. phosphate buffer; water; dimethyl sulfoxide; at 30 ℃; for 24h; pH=7; enantioselective reaction; Enzymatic reaction;

DOI:10.1021/acs.orglett.0c00802

Reference yield: 60.0%

5-(3-chlorophenyl)-3,4-dihydro-2H-pyrrole (374588-99-5) → (S)-2-(3-chlorophenyl)pyrrolidine (1217756-62-1)

Guidance literature:

With hydrogenchloride; 2,3,4,5,6-pentahydroxy-hexanal; nicotinamide adenine dinucleotide phosphate; In aq. phosphate buffer; water; dimethyl sulfoxide; at 30 ℃; for 24h; pH=7; enantioselective reaction; Enzymatic reaction;

DOI:10.1021/acs.orglett.0c00802

upstream raw materials:

1-ethenyl-2-pyrrolidinone

3-chloro-benzoic acid ethyl ester

3-chlorobenzoate

5-(3-chlorophenyl)-3,4-dihydro-2H-pyrrole

Downstream raw materials:

C₂₀H₂₃ClN₂O₃S

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