1-Boc-5-broMo-1H-pyrazolo[3,4-b]pyridine

Base Information

• Chemical Name: 1-Boc-5-broMo-1H-pyrazolo[3,4-b]pyridine
• CAS No.: 1299607-55-8
• Molecular Formula: C₁₁H₁₂BrN₃O₂
• Molecular Weight: 298.139
• Hs Code.: 2933990090
• Mol file: 1299607-55-8.mol

Synonyms:1-Boc-5-broMo-1H-pyrazolo[3,4-b]pyridine;5-Bromo-1H-pyrazolo[3,4-b]pyridine-1-carboxylic acid 1,1-dimethylethyl ester

Chemical Property of 1-Boc-5-broMo-1H-pyrazolo[3,4-b]pyridine

Chemical Property:

• Boiling Point: 371.5±45.0 °C(Predicted)
• PKA: -1.04±0.30(Predicted)
• PSA: 57.01000
• Density: 1.55±0.1 g/cm3(Predicted)
• LogP: 2.97700
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1-Boc-5-bromo-1H-pyrazolo[3,4-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-5-broMo-1H-pyrazolo[3,4-b]pyridine

There total 6 articles about 1-Boc-5-broMo-1H-pyrazolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-bromo-7-azaindazole (875781-17-2,916257-29-9) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 5-bromo-1H-pyrazolo[3,4-b]pyridine-1-carboxylate (1299607-55-8)

Guidance literature:

With dmap; triethylamine; In acetonitrile; at 20 ℃; for 3.25h; Inert atmosphere;

Reference yield:

5-bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine (875781-18-3) → tert-butyl 5-bromo-1H-pyrazolo[3,4-b]pyridine-1-carboxylate (1299607-55-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / DMAP; Et₃N / tetrahydrofuran

2: t-BuLi

With dmap; tert.-butyl lithium; triethylamine; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2006.12.031

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 5-bromo-1H-pyrazolo[3,4-b]pyridine-1-carboxylate (1299607-55-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / DMAP; Et₃N / tetrahydrofuran

2: t-BuLi

With dmap; tert.-butyl lithium; triethylamine; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2006.12.031

upstream raw materials:

tert-butyl 5-bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine-1-carboxylate

N,N-dimethyl-formamide

5-bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine

di-tert-butyl dicarbonate

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