TAS-116

Base Information

Chemical Name:TAS-116
CAS No.:1260533-36-5
Molecular Formula:C25H26N8O
Molecular Weight:454.53
Hs Code.:
Mol file:1260533-36-5.mol

Synonyms:TAS-116

Suppliers and Price of TAS-116

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
TAS-116 >96%
100 mg
$ 750.00

DC Chemicals
TAS-116 >96%
250 mg
$ 1350.00

ChemScene
TAS-116 98.96%
10mg
$ 1450.00

ChemScene
TAS-116 98.96%
5mg
$ 85.00

ChemScene
TAS-116 98.96%
100mg
$ 940.00

ChemScene
TAS-116 98.96%
50mg
$ 530.00

American Custom Chemicals Corporation
TAS-116 95.00%
5MG
$ 503.05

Total 11 raw suppliers

Chemical Property of TAS-116

Chemical Property:

Boiling Point:661.7±55.0 °C(Predicted)
PKA:15.43±0.50(Predicted)
PSA：109.44000
Density:1.36±0.1 g/cm3(Predicted)
LogP:4.49170

Purity/Quality:

99%, ^*data from raw suppliers

TAS-116 >96% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of TAS-116

There total 8 articles about TAS-116 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 3-ethyl-4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)benzonitrile

: 1260533-36-5
3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide

Guidance literature:: With dihydrogen peroxide; sodium hydroxide; In ethanol; water; dimethyl sulfoxide; at 0 - 20 ℃; for 2.5h;
DOI:10.1021/acs.jmedchem.8b01085

Reference yield: 15.0%

: 1260533-36-5
3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide

Guidance literature:

Reference yield:

: 1260539-02-3
4-iodo-3-isopropyl-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine

: 1260533-36-5
3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 4,7-dimethoxy-1,10-phenanthroline; caesium carbonate; copper(I) oxide / dimethyl sulfoxide / 24 h / 110 °C / Inert atmosphere

2: methoxybenzene; trifluoroacetic acid / 5 h / Reflux

3: caesium carbonate / N,N-dimethyl-formamide / 14 h / 120 °C / Inert atmosphere

4: sodium hydroxide; dihydrogen peroxide / water; ethanol; dimethyl sulfoxide / 2.5 h / 0 - 20 °C

With copper(I) oxide; 4,7-dimethoxy-1,10-phenanthroline; dihydrogen peroxide; caesium carbonate; methoxybenzene; trifluoroacetic acid; sodium hydroxide; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.8b01085