4-METHOXY-3-PYRAZOL-1-YLMETHYL-BENZYLAMINE

Base Information

• Chemical Name: 4-METHOXY-3-PYRAZOL-1-YLMETHYL-BENZYLAMINE
• CAS No.: 956352-90-2
• Molecular Formula: C12H15N3O
• Molecular Weight: 217.271
• Hs Code.: 2933199090
• Mol file: 956352-90-2.mol

Synonyms:4-METHOXY-3-PYRAZOL-1-YLMETHYL-BENZYLAMINE;[4-METHOXY-3-(1H-PYRAZOL-1-YLMETHYL)BENZYL]AMINE;[4-METHOXY-3-(1H-PYRAZOL-1-YLMETHYL)PHENYL]METHANAMINE;AKOS PAO-1230;TIMTEC-BB SBB011365;1-[4-methoxy-3-(1H-pyrazol-1-ylmethyl)phenyl]methanamine

Chemical Property of 4-METHOXY-3-PYRAZOL-1-YLMETHYL-BENZYLAMINE

Chemical Property:

• PSA: 53.07000
• LogP: 2.09900

Purity/Quality:

98%min ^*data from raw suppliers

[4-methoxy-3-(1H-pyrazol-1-ylmethyl)phenyl]methanamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXY-3-PYRAZOL-1-YLMETHYL-BENZYLAMINE

There total 3 articles about 4-METHOXY-3-PYRAZOL-1-YLMETHYL-BENZYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

C12H13N3O2 → [4-methoxy-3-(1H-pyrazol-1-ylmethyl)benzyl]amine (956352-90-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/j.mencom.2018.05.028

Reference yield:

3-((1H-pyrazol-1-yl)methyl)-4-methoxybenzaldehyde (436086-89-4) → [4-methoxy-3-(1H-pyrazol-1-ylmethyl)benzyl]amine (956352-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; pyridine / ethanol

2: lithium aluminium tetrahydride / tetrahydrofuran

With pyridine; lithium aluminium tetrahydride; hydroxylamine hydrochloride; In tetrahydrofuran; ethanol;

DOI:10.1016/j.mencom.2018.05.028

Reference yield:

3-(chloromethyl)-4-methoxybenzaldehyde (52577-09-0) → [4-methoxy-3-(1H-pyrazol-1-ylmethyl)benzyl]amine (956352-90-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 18-crown-6 ether; potassium hydroxide / benzene; water / 80 °C

2: hydroxylamine hydrochloride; pyridine / ethanol

3: lithium aluminium tetrahydride / tetrahydrofuran

With pyridine; lithium aluminium tetrahydride; 18-crown-6 ether; hydroxylamine hydrochloride; potassium hydroxide; In tetrahydrofuran; ethanol; water; benzene;

DOI:10.1016/j.mencom.2018.05.028

upstream raw materials:

3-(chloromethyl)-4-methoxybenzaldehyde

3-((1H-pyrazol-1-yl)methyl)-4-methoxybenzaldehyde

Downstream raw materials:

6-[4-methoxy-3-(1H-pyrazol-1-ylmethyl)benzyl]-1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.1^3,11]tetradecane-4,8,12-trione

3,7-bis{N-[4-methoxy-3-(1H-pyrazol-1-ylmethyl)benzyl]glycyl}-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one

Refernces