3-IODO-5-NITRO-6-METHYL (1H)INDAZOLE

Base Information

• Chemical Name: 3-IODO-5-NITRO-6-METHYL (1H)INDAZOLE
• CAS No.: 1000343-55-4
• Molecular Formula: C8H6IN3O2
• Molecular Weight: 303.05661
• Mol file: 1000343-55-4.mol

Synonyms:3-IODO-5-NITRO-6-METHYL (1H)INDAZOLE;3-iodo-6-methyl-5-nitro-1H-Indazole

Chemical Property of 3-IODO-5-NITRO-6-METHYL (1H)INDAZOLE

Chemical Property:

• PSA: 74.50000
• LogP: 2.90730
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

95% ^*data from raw suppliers

3-Iodo-6-methyl-5-nitro-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Iodo-6-methyl-5-nitro-1H-indazole is used as a reactant in the synthesis of alkenyl indazoles as selective Aurora kinase inhibitors.

Technology Process of 3-IODO-5-NITRO-6-METHYL (1H)INDAZOLE

There total 1 articles about 3-IODO-5-NITRO-6-METHYL (1H)INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

6-methyl-5-nitro-1H-indazole (81115-43-7) → 3-iodo-6-methyl-5-nitro-1H-indazole (1000343-55-4)

Guidance literature:

With iodine; potassium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2010.03.018

upstream raw materials:

6-methyl-5-nitro-1H-indazole

Refernces

• 1、 Blanchard, Stéphanie,William, Anthony D.,Lee, Angeline C.-H.,Poulsen, Anders,Teo, Ee Ling,Deng, Weiping,Tu, Noah,Tan, Evelyn,Goh, Kay Lin,Ong, Wai Chung,Ng, Chee Pang,Goh, Kee Chuan,Bonday, Zahid,Sun, Eric T.. "Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors". scheme or table. p. 2443 - 2447. Retrieved 2010/07/16.