2-[(2S)-2-Amino-3-(3-fluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione

Base Information

Chemical Name:2-[(2S)-2-Amino-3-(3-fluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione
CAS No.:943325-38-0
Molecular Formula:C17H15FN2O2
Molecular Weight:298.317
Hs Code.:
Mol file:943325-38-0.mol

Synonyms:2-[(2S)-2-Amino-3-(3-fluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione;(S)-2-(2-amino-3-(3-fluorophenyl)propyl)isoindoline-1,3-dione;(S)-2-(2-amino-3-(3-fluorophenyl)propyl)isoindoline-1,3-dione hydrochloride

Suppliers and Price of 2-[(2S)-2-Amino-3-(3-fluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
(S)-2-(2-Amino-3-(3-fluorophenyl)propyl)isoindoline-1,3-dione 95+%
1g
$ 421.00

Alichem
(S)-2-(2-Amino-3-(3-fluorophenyl)propyl)isoindoline-1,3-dione
1g
$ 486.00

Alichem
(S)-2-(2-Amino-3-(3-fluorophenyl)propyl)isoindoline-1,3-dione
250mg
$ 190.80

Total 7 raw suppliers

Chemical Property of 2-[(2S)-2-Amino-3-(3-fluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione

Chemical Property:

PSA：63.40000
LogP:2.62990

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-(2-Amino-3-(3-fluorophenyl)propyl)isoindoline-1,3-dione 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[(2S)-2-Amino-3-(3-fluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione

There total 4 articles about 2-[(2S)-2-Amino-3-(3-fluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201923-48-9
1,1-dimethylethyl {(1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-[(3-fluorophenyl)methyl]ethyl}carbamate

: 943325-38-0
2-[(2S)-2-amino-3-(3-fluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione

Guidance literature:: With hydrogenchloride; In methanol;
DOI:10.1358/dof.2014.039.08.2177902

Reference yield:

: 114873-01-7,114873-11-9
N-Boc-3-fluoro-L-phenylalanine

: 943325-38-0
2-[(2S)-2-amino-3-(3-fluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran

3: hydrogenchloride / methanol

With hydrogenchloride; borane-THF; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol; 2: |Mitsunobu Displacement;
DOI:10.1358/dof.2014.039.08.2177902

Reference yield:

: 944470-56-8,1199781-37-7
tert-butyl [(1S)-1-(3-fluorobenzyl)-2-hydroxyethyl]carbamate

: 943325-38-0
2-[(2S)-2-amino-3-(3-fluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran

2: hydrogenchloride / methanol

With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol; 1: |Mitsunobu Displacement;
DOI:10.1358/dof.2014.039.08.2177902