2H-1-Benzopyran-8-aMine, 3,4-dihydro-

Base Information

• Chemical Name: 2H-1-Benzopyran-8-aMine, 3,4-dihydro-
• CAS No.: 113722-25-1
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.192
• Mol file: 113722-25-1.mol

Synonyms:2H-1-Benzopyran-8-aMine, 3,4-dihydro-;chroMan-8-aMine;Chroman-8-ylamine;3,4-DIHYDRO-2H-1-BENZOPYRAN-8-AMINE

Chemical Property of 2H-1-Benzopyran-8-aMine, 3,4-dihydro-

Chemical Property:

• Boiling Point: 291.3±29.0 °C(Predicted)
• PKA: 4.62±0.20(Predicted)
• PSA: 35.25000
• Density: 1.151±0.06 g/cm3(Predicted)
• LogP: 2.17500

Purity/Quality:

≥95% ^*data from raw suppliers

3,4-Dihydro-2H-1-benzopyran-8-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-1-Benzopyran-8-aMine, 3,4-dihydro-

There total 6 articles about 2H-1-Benzopyran-8-aMine, 3,4-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

8-nitro-2H-chromene → chroman-8-amine (113722-25-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; ethyl acetate; at 20 ℃; for 20h; under 760.051 Torr;

Reference yield:

2-allyloxy-1-nitro-3-vinyl-benzene → chroman-8-amine (113722-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 6 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate; tetrahydrofuran / 20 h / 20 °C / 760.05 Torr

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;

Reference yield:

2-fluoro-3-bromonitrobenzene (58534-94-4) → chroman-8-amine (113722-25-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 3.5 h / 90 °C / Inert atmosphere

2: potassium carbonate / 16 h / 60 °C

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 6 h / 20 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate; tetrahydrofuran / 20 h / 20 °C / 760.05 Torr

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate;

upstream raw materials:

chromane

2-fluoro-3-bromonitrobenzene

Refernces

• 1、 -. "7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES". . . Retrieved 2020/07/07.