Cyclohexanepropanoic acid, -ba--hydroxy--alpha--methyl-, methyl ester, (-alpha-S,-ba-S)- (9CI)

Base Information

• Chemical Name: Cyclohexanepropanoic acid, -ba--hydroxy--alpha--methyl-, methyl ester, (-alpha-S,-ba-S)- (9CI)
• CAS No.: 620164-01-4
• Molecular Formula: C11H20O3
• Molecular Weight: 200.27
• Mol file: 620164-01-4.mol

Synonyms:Cyclohexanepropanoicacid,-bta--hydroxy--alpha--methyl-,methylester,(-alpha-S,-bta-S)-(9CI);Cyclohexanepropanoic acid, -ba--hydroxy--alpha--methyl-, methyl ester, (-alpha-S,-ba-S)- (9CI);Cyclohexanepropanoic acid, -b

Chemical Property of Cyclohexanepropanoic acid, -ba--hydroxy--alpha--methyl-, methyl ester, (-alpha-S,-ba-S)- (9CI)

Chemical Property:

• PSA: 46.53000
• LogP: 1.73670

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexanepropanoic acid, -ba--hydroxy--alpha--methyl-, methyl ester, (-alpha-S,-ba-S)- (9CI)

There total 4 articles about Cyclohexanepropanoic acid, -ba--hydroxy--alpha--methyl-, methyl ester, (-alpha-S,-ba-S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + cyclohexanecarbaldehyde (2043-61-0) → methyl (2S,3S)-3-cyclohexyl-3-hydroxy-2-methylpropionate (620164-01-4) + (-)-methyl (2R,3R)-3-cyclohexyl-3-hydroxy-2-methylpropionate (78604-73-6) + (2R,3S)-methyl 3-cyclohexyl-3-hydroxy-2-methylpropanoate (142130-57-2) + (2S,3R)-methyl 3-cyclohexyl-3-hydroxy-2-methylpentanoate

Guidance literature:

With (PPh₃)₃CuF; ((SP)-1-[(S)-α-(dimethylamino)-2-(diphenylphosphino)benzyl]-2-diphenylphosphinoferrocene); phenylsilane; In toluene; at -50 ℃; for 1h; Title compound not separated from byproducts;

DOI:10.1021/ol062398v

Reference yield:

C10H18O3 (131897-91-1) + diazomethyl-trimethyl-silane (18107-18-1) → methyl (2S,3S)-3-cyclohexyl-3-hydroxy-2-methylpropionate (620164-01-4)

Guidance literature:

In methanol; hexane;

Reference yield:

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + cyclohexanecarbaldehyde (2043-61-0) → methyl (2S,3S)-3-cyclohexyl-3-hydroxy-2-methylpropionate (620164-01-4) + (-)-methyl (2R,3R)-3-cyclohexyl-3-hydroxy-2-methylpropionate (78604-73-6) + (2S,3R)-methyl 3-cyclohexyl-3-hydroxy-2-methylpentanoate

Guidance literature:

With (PPh₃)₃CuF; ((SP)-1-[(S)-α-(dimethylamino)-2-(diphenylphosphino)benzyl]-2-diphenylphosphinoferrocene); diphenylsilane; In toluene; at -50 ℃; for 1h; Title compound not separated from byproducts;

DOI:10.1021/ol062398v

upstream raw materials:

diazomethane

(3S,4R,1'R,2'S,5'R,1Z)-4-Cyclohexyl-4-hydroxy-1-(2-isopropyl-5-methylcyclohexyloxymethoxy)-3-methylbut-1-ene

acrylic acid methyl ester

cyclohexanecarbaldehyde