5-(3-NITROPHENYL)-3-ISOXAZOLECARBOXYLIC ACID

Base Information

• Chemical Name: 5-(3-NITROPHENYL)-3-ISOXAZOLECARBOXYLIC ACID
• CAS No.: 199601-80-4
• Molecular Formula: C₁₀H₆N₂O₅
• Molecular Weight: 234.168
• Hs Code.: 2934999090
• Mol file: 199601-80-4.mol

Synonyms:5-(3-NITROPHENYL)-3-ISOXAZOLECARBOXYLIC ACID;5-(3-Nitrophenyl)isoxazole-3-carboxylic Acid

Chemical Property of 5-(3-NITROPHENYL)-3-ISOXAZOLECARBOXYLIC ACID

Chemical Property:

• PSA: 109.15000
• LogP: 2.47120
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-(3-Nitrophenyl)isoxazole-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(3-NITROPHENYL)-3-ISOXAZOLECARBOXYLIC ACID

There total 6 articles about 5-(3-NITROPHENYL)-3-ISOXAZOLECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

5-(3-nitrophenyl)-isoxazole-3-carbonitrile (199602-07-8) → 5-(3-nitrophenyl)-isoxazole-3-carboxylic acid (199601-80-4)

Guidance literature:

With sodium hydroxide; In ethanol; for 1h; Heating;

DOI:10.1021/jm970467t

Reference yield:

1-nitro-3-vinyl-benzene (586-39-0,51209-60-0) → 5-(3-nitrophenyl)-isoxazole-3-carboxylic acid (199601-80-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 47 percent / aq. Na₂CO₃ / diethyl ether / Ambient temperature

2: 1.4 percent / NBS, dibenzoyl peroxide / CCl₄ / Heating

3: 24 percent / aq. NaOH / ethanol / 1 h / Heating

With sodium hydroxide; N-Bromosuccinimide; sodium carbonate; dibenzoyl peroxide; In tetrachloromethane; diethyl ether; ethanol;

DOI:10.1021/jm970467t

Reference yield:

5-(3-nitrophenyl)-4,5-dihydroisoxazole-3-carbonitrile (199601-82-6) → 5-(3-nitrophenyl)-isoxazole-3-carboxylic acid (199601-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.4 percent / NBS, dibenzoyl peroxide / CCl₄ / Heating

2: 24 percent / aq. NaOH / ethanol / 1 h / Heating

With sodium hydroxide; N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; ethanol;

DOI:10.1021/jm970467t

upstream raw materials:

5-(3-nitrophenyl)-isoxazole-3-carbonitrile

1-nitro-3-vinyl-benzene

5-(3-nitrophenyl)-4,5-dihydroisoxazole-3-carbonitrile

ethyl 5-(3-nitrophenyl)isoxazole-3-carboxylate

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