2H-Isoxazolo[3,2-a]isoquinoline,2-ethoxy-1,5,6,10b-tetrahydro-,(2S,10bS)-(9CI)

Base Information

Chemical Name:2H-Isoxazolo[3,2-a]isoquinoline,2-ethoxy-1,5,6,10b-tetrahydro-,(2S,10bS)-(9CI)
CAS No.:327187-97-3
Molecular Formula:C₁₃H₁₇NO₂
Molecular Weight:219.283
Hs Code.:
Mol file:327187-97-3.mol

Synonyms:2H-Isoxazolo[3,2-a]isoquinoline,2-ethoxy-1,5,6,10b-tetrahydro-,(2S,10bS)-(9CI)

Suppliers and Price of 2H-Isoxazolo[3,2-a]isoquinoline,2-ethoxy-1,5,6,10b-tetrahydro-,(2S,10bS)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 2H-Isoxazolo[3,2-a]isoquinoline,2-ethoxy-1,5,6,10b-tetrahydro-,(2S,10bS)-(9CI)

Chemical Property:

PSA：21.70000
LogP:2.22160

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2H-Isoxazolo[3,2-a]isoquinoline,2-ethoxy-1,5,6,10b-tetrahydro-,(2S,10bS)-(9CI)

There total 8 articles about 2H-Isoxazolo[3,2-a]isoquinoline,2-ethoxy-1,5,6,10b-tetrahydro-,(2S,10bS)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24423-87-8,65194-03-8
3,4-dihydro-isoquinoline 2-oxide

: 109-92-2,25104-37-4
ethyl vinyl ether

: 196393-15-4,215509-18-5,327187-97-3
cis-1,5,6,10b-tetrahydro-2H-isoxazolo[3,2-a]isoquinolin-2-yl ethyl ether

: 196393-15-4,215509-18-5,327187-97-3
trans-1,5,6,10b-tetrahydro-2H-isoxazolo[3,2-a]isoquinolin-2-yl ethyl ether

Guidance literature:: With bis(acetonitrile)((S)-TolBINAP)paladium di(tetrafluoroborate); In chloroform; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;
DOI:10.1016/S0040-4020(98)00776-5

Reference yield:

: 24423-87-8,65194-03-8
3,4-dihydro-isoquinoline 2-oxide

: 109-92-2,25104-37-4
ethyl vinyl ether

: 196393-15-4,215509-18-5,327187-97-3
cis-1,5,6,10b-tetrahydro-2H-isoxazolo[3,2-a]isoquinolin-2-yl ethyl ether

: 196393-15-4,215509-18-5,327187-97-3
trans-1,5,6,10b-tetrahydro-2H-isoxazolo[3,2-a]isoquinolin-2-yl ethyl ether

Guidance literature:: With bis(acetonitrile)((S)-TolBINAP)paladium di(tetrafluoroborate); In chloroform; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;
DOI:10.1016/S0040-4020(98)00776-5

Reference yield:

: 24423-87-8,65194-03-8
3,4-dihydro-isoquinoline 2-oxide

: 109-92-2,25104-37-4
ethyl vinyl ether

: 215509-18-5,327187-97-3
C₁₃H₁₇NO₂

: 196393-15-4,215509-18-5,327187-97-3
(-)-(2S,10bS)-2-ethoxy-1,5,6,10b-tetrahydro-2H-isoxazolo[3,2-a]isoquinoline

: 196393-15-4,215509-18-5,327187-97-3
(+)-(2R,10bR)-2-ethoxy-1,5,6,10b-tetrahydro-2H-isoxazolo[3,2-a]isoquinoline

Guidance literature:: With (R_a)-4-hydroxy-2,6-bis(2,4,6-tricyclohexylphenyl)dinaphtho-[1,3,2]dioxaphosphepine 4-oxide; In 1,3,5-trimethyl-benzene; at 20 ℃; for 40h; Overall yield = 88 percent; enantioselective reaction; Inert atmosphere;
DOI:10.1055/s-0039-1690108