(3R,5S)-5-(Hydroxymethyl)-1-methylpyrrolidin-3-ol

Base Information

Chemical Name:(3R,5S)-5-(Hydroxymethyl)-1-methylpyrrolidin-3-ol
CAS No.:107797-60-4
Molecular Formula:C₆H₁₃NO₂
Molecular Weight:131.175
Hs Code.:
European Community (EC) Number:887-320-1
Mol file:107797-60-4.mol

Synonyms:(3R,5S)-5-(Hydroxymethyl)-1-methylpyrrolidin-3-ol;157087-65-5;107797-60-4;2-Pyrrolidinemethanol,4-hydroxy-1-methyl-,trans-(9CI);trans-5-(Hydroxymethyl)-1-methylpyrrolidin-3-ol;(2S,4R)-4-hydroxy-1-methyl-2-Pyrrolidinemethanol;SCHEMBL5321769;IXFHJDFJPFHQLP-NTSWFWBYSA-N;AT22831;EN300-6473146;(2S, 4R)-4-hydroxy-1-methyl-2-pyrrolidinemethanol

Suppliers and Price of (3R,5S)-5-(Hydroxymethyl)-1-methylpyrrolidin-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (3R,5S)-5-(Hydroxymethyl)-1-methylpyrrolidin-3-ol

Chemical Property:

XLogP3:-0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:131.094628657
Heavy Atom Count:9
Complexity:97.1

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CC(CC1CO)O
Isomeric SMILES:CN1C[C@@H](C[C@H]1CO)O

Technology Process of (3R,5S)-5-(Hydroxymethyl)-1-methylpyrrolidin-3-ol

There total 3 articles about (3R,5S)-5-(Hydroxymethyl)-1-methylpyrrolidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.5%

: 51-35-4,913000-57-4,30724-02-8
4-hydroxyproline

: 107797-60-4,157087-65-5
(2S,4R)-4-hydroxy-1-methyl-2-pyrrolidinemethanol

Guidance literature:: With formic acid; trifluoroborane diethyl ether; potassium carbonate; In tetrahydrofuran; methanol; sodium hydroxide; formaldehyd; dichloromethane; isopropyl alcohol;

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 107797-60-4,157087-65-5
(2S,4R)-4-hydroxy-1-methyl-2-pyrrolidinemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CHCl₃ / Ambient temperature

2: LiAlH₄ / tetrahydrofuran / Ambient temperature

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; chloroform;
DOI:10.1021/jo971791z