S-BENZYL-L-CYSTEINE SULFONE

Base Information

• Chemical Name: S-BENZYL-L-CYSTEINE SULFONE
• CAS No.: 25644-88-6
• Molecular Formula: C10H13NO4S
• Molecular Weight: 243.284
• Hs Code.: 2930909899
• Mol file: 25644-88-6.mol

Synonyms:S-BENZYL-L-CYSTEINE SULFONE;3-(Benzylsulfonyl)-L-alanine;3-[(PhenylMethyl)sulfonyl]-L-alanine

Chemical Property of S-BENZYL-L-CYSTEINE SULFONE

Chemical Property:

• Vapor Pressure: 1.33E-11mmHg at 25°C
• Melting Point: 174-176°C
• Boiling Point: 519.1°C at 760 mmHg
• PKA: 1.76±0.10(Predicted)
• Flash Point: 267.7°C
• PSA: 105.84000
• Density: 1.39g/cm³
• LogP: 1.79440
• Storage Temp.: -20°C Freezer
• Solubility.: Aqueous Acid (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

S-Benzyl-L-cysteine sulfone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A novel derivative of (R)-cysteine

Technology Process of S-BENZYL-L-CYSTEINE SULFONE

There total 4 articles about S-BENZYL-L-CYSTEINE SULFONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Benzyloxycarbonyl-S-benzyl-L-cystein-sulfon (884483-98-1) → (R)-2-amino-3-(benzylsulfonyl)propanoic acid (25644-88-6)

Guidance literature:

With hydrogen bromide; acetic acid;

DOI:10.1021/ja00888a018

Reference yield:

S-benzyl-L-cysteine (3054-01-1,25988-62-9) → (R)-2-amino-3-(benzylsulfonyl)propanoic acid (25644-88-6)

Guidance literature:

With ammonium molibdate; perchloric acid; dihydrogen peroxide;

DOI:10.1039/j39700000270

Reference yield:

benzyl chloride (100-44-7) → (R)-2-amino-3-(benzylsulfonyl)propanoic acid (25644-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1: liquid ammonia

2: aq. H₂O₂, HClO₄, (NH₄)2MoO₄

With ammonium molibdate; perchloric acid; dihydrogen peroxide; In ammonia;

DOI:10.1039/j39700000270

upstream raw materials:

S-benzyl-L-cysteine

N-Benzyloxycarbonyl-S-benzyl-L-cystein-sulfon

benzyl chloride

Downstream raw materials:

(R)-2-[(morpholine-4-carbonyl)-amino]-3-phenylmethanesulfonyl-propionic acid

(R)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-3-phenylmethanesulfonyl-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

L-cysteinesulfinic acid

Refernces

• 1、 Roy, Michael J.,Vom, Amelia,Okamoto, Toru,Smith, Brian J.,Birkinshaw, Richard W.,Yang, Hong,Abdo, Houda,White, Christine. A.,Segal, David,Huang, David C. S.,Baell, Jonathan B.,Colman, Peter M.,Czabotar, Peter E.,Lessene, Guillaume. "Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-XLand BCL-2". . p. 5447 - 5469. Retrieved 2021/05/31.