2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide

Base Information

Chemical Name:2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
CAS No.:442633-00-3
Molecular Formula:C18H17FN2O
Molecular Weight:296.344
Hs Code.:
Mol file:442633-00-3.mol

Synonyms:2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide;CK 666;CK-0944666

Suppliers and Price of 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
CK 666
10mg
$ 438.00

TRC
CK666
25mg
$ 285.00

Tocris
CK666 ≥99%(HPLC)
50
$ 818.00

Tocris
CK666 ≥99%(HPLC)
10
$ 195.00

Sigma-Aldrich
CK-666 ≥98% (HPLC), powder
25mg
$ 432.00

Sigma-Aldrich
CK-666 ≥98% (HPLC), powder
5mg
$ 108.00

Sigma-Aldrich
Arp2/3 Complex Inhibitor I, CK-666
25mg
$ 181.00

ChemScene
CK-666 99.63%
50mg
$ 650.00

ChemScene
CK-666 99.63%
10mg
$ 160.00

ChemScene
CK-666 99.63%
5mg
$ 90.00

Total 10 raw suppliers

Chemical Property of 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide

Chemical Property:

Boiling Point:528.2±50.0 °C(Predicted)
PKA:13.86±0.46(Predicted)
PSA：48.38000
Density:1.235±0.06 g/cm3(Predicted)
LogP:4.16270
Storage Temp.:Store at -20°C
Solubility.:DMSO: ≥25mg/mL

Purity/Quality:

97% ^*data from raw suppliers

CK 666 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Description CK-666 (442633-00-3) is a potent, selective and reversible inhibitor of ARP2/3 complex (actin related proteins 2 and 3) with an IC50?= 4 μM for human ARP2/3.1?Blocks actin nucleation and radically alters lamellipodial actin architecture, suspended cell shape and the cell spreading process.2 CK-666 attenuates BBB dysfunction induced by methamphetamine.3?It is an important new tool for studying actin assembly and the diverse range of actin-related processes in normal4 and pathophysiology5.
Uses CK-666 may be used to study Arp2/3-mediated structural changes in cells.

Technology Process of 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide

There total 4 articles about 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2731-06-8
2-methyltryptamine

: 393-52-2
2-Fluorobenzoyl chloride

: 442633-00-3
2-fluoro-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1002/cmdc.201200104

Reference yield:

: 2826-91-7
C₁₁H₁₀N₂O₂

: 442633-00-3
2-fluoro-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / tetrahydrofuran

2: palladium 10% on activated carbon; ammonium formate / methanol

3: triethylamine / tetrahydrofuran / 0.5 h / 20 °C

With palladium 10% on activated carbon; ammonium formate; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1002/cmdc.201200104

Reference yield:

: 95-20-5
2-methyl-1H-indole

: 442633-00-3
2-fluoro-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / N,N-dimethyl-formamide

2: ammonium acetate

3: sodium tris(acetoxy)borohydride / tetrahydrofuran

4: palladium 10% on activated carbon; ammonium formate / methanol

5: triethylamine / tetrahydrofuran / 0.5 h / 20 °C

With palladium 10% on activated carbon; ammonium acetate; ammonium formate; sodium tris(acetoxy)borohydride; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201200104