2-Bromo-6-methoxy-5-(trifluoromethyl)-1-naphthoic acid

Base Information

• Chemical Name: 2-Bromo-6-methoxy-5-(trifluoromethyl)-1-naphthoic acid
• CAS No.: 122670-62-6
• Molecular Formula: C13H8BrF3O3
• Molecular Weight: 349.1
• Hs Code.: 2918990090
• Mol file: 122670-62-6.mol

Synonyms:2-Bromo-6-methoxy-5-(trifluoromethyl)-1-naphthoic acid

Chemical Property of 2-Bromo-6-methoxy-5-(trifluoromethyl)-1-naphthoic acid

Chemical Property:

• Melting Point: 221-222.5 °C
• Boiling Point: 448.8±45.0 °C(Predicted)
• PSA: 46.53000
• Density: 1.664±0.06 g/cm3(Predicted)
• LogP: 4.32790

Purity/Quality:

≥99% ^*data from raw suppliers

2-Bromo-6-methoxy-5-(trifluoromethyl)-1-naphthoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-6-methoxy-5-(trifluoromethyl)-1-naphthoic acid

There total 7 articles about 2-Bromo-6-methoxy-5-(trifluoromethyl)-1-naphthoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-Bromo-5-(trifluoromethyl)-6-methoxy-1-naphthalene-methanol (122670-61-5) → 2-Bromo-5-(trifluoromethyl)-6-methoxy-1-naphthalene-carboxylic acid (122670-62-6)

Guidance literature:

With jones reagent; In acetone; 1.) 0 deg C, 5 min, then room temperature, 1 h;

DOI:10.1021/jo00296a028

Reference yield: 67.0%

jones reagent + 2-Bromo-5-(trifluoromethyl)-6-methoxy-1-naphthalene-methanol (122670-61-5) → 2-Bromo-5-(trifluoromethyl)-6-methoxy-1-naphthalene-carboxylic acid (122670-62-6)

Guidance literature:

In CrO₃; acetone;

Reference yield:

2-bromo-6-methoxy-1-methyl-5-(trifluoromethyl)naphthalene (122670-67-1) → 2-Bromo-5-(trifluoromethyl)-6-methoxy-1-naphthalene-carboxylic acid (122670-62-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / NBS; benzoyl peroxide / CCl₄ / 18 h / Heating

2: 43 percent / NaOH / ethanol / 48 h

3: 67 percent / Jones reagent / acetone / 2 h

With sodium hydroxide; N-Bromosuccinimide; jones reagent; dibenzoyl peroxide; In tetrachloromethane; ethanol; acetone;

DOI:10.1016/j.bmcl.2004.06.013

upstream raw materials:

2-Bromo-5-(trifluoromethyl)-6-methoxy-1-naphthalene-methanol

2-bromo-6-methoxy-1-methyl-5-(trifluoromethyl)naphthalene

2-Bromo-1-(bromomethyl)-5-(trifluoromethyl)-6-methoxynaphthalene

2-methoxy-5-methyl-6-nitro-1-(trifluorormethyl)naphthalene

Downstream raw materials:

N-[[6-methoxy-2-phenoxy-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-methylglycine

N-[[6-methoxy-2-phenoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglycine

[(6-Methoxy-2-phenoxy-5-trifluoromethyl-naphthalene-1-carbonyl)-methyl-amino]-acetic acid methyl ester

[(6-Methoxy-2-phenoxy-5-trifluoromethyl-naphthalene-1-carbothioyl)-methyl-amino]-acetic acid methyl ester