Benzoic acid, 2-[(3-hydroxybenzoyl)amino]- (9CI)

Base Information

• Chemical Name: Benzoic acid, 2-[(3-hydroxybenzoyl)amino]- (9CI)
• CAS No.: 697235-58-8
• Molecular Formula: C₁₄H₁₁NO₄
• Molecular Weight: 257.246
• Mol file: 697235-58-8.mol

Synonyms:Benzoic acid, 2-[(3-hydroxybenzoyl)amino]- (9CI)

Chemical Property of Benzoic acid, 2-[(3-hydroxybenzoyl)amino]- (9CI)

Chemical Property:

• PSA: 86.63000
• LogP: 2.41570

Purity/Quality:

2-[(3-HYDROXYBENZOYL)AMINO]-BENZOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 2-[(3-hydroxybenzoyl)amino]- (9CI)

There total 5 articles about Benzoic acid, 2-[(3-hydroxybenzoyl)amino]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) + 3-Carboxyphenol (99-06-9) → N-(3-hydroxybenzoyl)anthranilic acid (697235-58-8)

Guidance literature:

With pDRf₁-(4-coumaroyl:CoA ligase 5 from Arabidopsis thaliana)-(hydroxycinnamoyl/benzoyl-CoA:anthranilate N-hydroxycinnamoyl/benzoyltransferase 1 from Dianthus caryophyllus) recombinant yeast; In dimethyl sulfoxide; at 30 ℃; for 24h;

DOI:10.1371/journal.pone.0138972

Reference yield:

C15H13NO4 (1156230-86-2) → N-(3-hydroxybenzoyl)anthranilic acid (697235-58-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; at 20 ℃;

Reference yield:

3-Carboxyphenol (99-06-9) → N-(3-hydroxybenzoyl)anthranilic acid (697235-58-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; thionyl chloride / dichloromethane / 45 °C

2: toluene / Reflux

3: sodium hydroxide / tetrahydrofuran; 1,4-dioxane / 20 °C

With pyridine; thionyl chloride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;

upstream raw materials:

C₁₅H₁₃NO₄

3-hydroxybenzoyl chloride

3-Carboxyphenol

anthranilic acid

Refernces

• 1、 Emenike, Bright U.,Liu, Albert Tianxiang,Naveo, Elsy P.,Roberts, John D.. "Substituent effects on energetics of peptide-carboxylate hydrogen bonds as studied by 1H NMR spectroscopy: Implications for enzyme catalysis". . p. 11765 - 11771. Retrieved 2014/01/06.