tert-butyl N-{3-aminobicyclo[1.1.1]pentan-1-yl}carbamate

Base Information

• Chemical Name: tert-butyl N-{3-aminobicyclo[1.1.1]pentan-1-yl}carbamate
• CAS No.: 1638767-25-5
• Molecular Formula: C₁₀H₁₈N₂O₂
• Molecular Weight: 198.265
• Hs Code.: 2924297099
• Mol file: 1638767-25-5.mol

Synonyms:tert-butyl N-{3-aminobicyclo[1.1.1]pentan-1-yl}carbamate;tert-Butyl (3-aminobicyclo[1.1.1]pentan-1-yl)carbamate

Chemical Property of tert-butyl N-{3-aminobicyclo[1.1.1]pentan-1-yl}carbamate

Chemical Property:

• Boiling Point: 288.9±39.0 °C(Predicted)
• PKA: 9.98±0.20(Predicted)
• PSA: 64.35000
• Density: 1.14±0.1 g/cm3(Predicted)
• LogP: 2.23610
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99%, ^*data from raw suppliers

N-(3-Aminobicyclo[1.1.1]pent-1-yl)carbamicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N-{3-aminobicyclo[1.1.1]pentan-1-yl}carbamate

There total 4 articles about tert-butyl N-{3-aminobicyclo[1.1.1]pentan-1-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzyl tert-butyl bicyclo[1.1.1]pentane-1,3-diyldicarbamate → tert-butyl N-(1-amino-3-bicyclo[1.1.1]pentanyl)carbamate (1638767-25-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol;

DOI:10.1002/ejoc.201701296

Reference yield: 75.0%

di-tert-butyl dicarbonate (24424-99-5) + <1>staffane-1,3-diamine dihydrochloride → tert-butyl N-(1-amino-3-bicyclo[1.1.1]pentanyl)carbamate (1638767-25-5)

Guidance literature:

With sodium methylate; In methanol; at 0 - 10 ℃; for 6h; Inert atmosphere; Large scale;

Reference yield:

3-((tert-butoxycarbonyl)amino)bicyclo[1.1.1]pentane-1-carboxylic acid (303752-38-7) → tert-butyl N-(1-amino-3-bicyclo[1.1.1]pentanyl)carbamate (1638767-25-5)

Guidance literature:

3-((tert-butoxycarbonyl)amino)bicyclo[1.1.1]pentane-1-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In tert-butyl alcohol;

With hydrogenchloride; In water;

DOI:10.1002/ejoc.201701296

upstream raw materials:

3-((tert-butoxycarbonyl)amino)bicyclo[1.1.1]pentane-1-carboxylic acid

3-((tert-butoxycarbonyl)amino)bicyclo[1.1.1]pentane-1-carboxylic acid methyl ester

di-tert-butyl dicarbonate

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