1,6-dichloro-2,7-naphthyridine

Base Information

• Chemical Name: 1,6-dichloro-2,7-naphthyridine
• CAS No.: 1335053-95-6
• Molecular Formula: C8H4Cl2N2
• Molecular Weight: 199.03676
• Hs Code.: 29339900
• Mol file: 1335053-95-6.mol

Synonyms:1,6-dichloro-2,7-naphthyridine

Chemical Property of 1,6-dichloro-2,7-naphthyridine

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,6-Dichloro-2,7-naphthyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,6-dichloro-2,7-naphthyridine

There total 7 articles about 1,6-dichloro-2,7-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

6-chloro-1,2-dihydro-2,7-naphthyridin-1-one → 1,6-dichloro-2,7-naphthyridine (1335053-95-6)

Guidance literature:

With trichlorophosphate; at 160 ℃; for 4h;

Reference yield:

2,6-dichloro-4-methylnicotinonitrile (875-35-4) → 1,6-dichloro-2,7-naphthyridine (1335053-95-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: isopropyl alcohol / 18 h / 65 °C

2.1: hydrogenchloride / water / 18 h / 45 °C / Sealed tube

3.1: hydrazine hydrate / isopropyl alcohol / 0 - 55 °C

4.1: sodium hydroxide / water; acetonitrile / 50 °C

4.2: 0 - 20 °C

5.1: trichlorophosphate / 4 h / 160 °C

With hydrogenchloride; hydrazine hydrate; sodium hydroxide; trichlorophosphate; In water; isopropyl alcohol; acetonitrile;

Reference yield:

2,6-dichloro-4-[(E)-2-(dimethylamino)ethenyl]pyridine-3-carbonitrile (1175559-53-1) → 1,6-dichloro-2,7-naphthyridine (1335053-95-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 18 h / 45 °C / Sealed tube

2.1: hydrazine hydrate / isopropyl alcohol / 0 - 55 °C

3.1: sodium hydroxide / water; acetonitrile / 50 °C

3.2: 0 - 20 °C

4.1: trichlorophosphate / 4 h / 160 °C

With hydrogenchloride; hydrazine hydrate; sodium hydroxide; trichlorophosphate; In water; isopropyl alcohol; acetonitrile;

upstream raw materials:

2,6-dichloro-4-methylnicotinonitrile

2,6-dichloro-4-[(E)-2-(dimethylamino)ethenyl]pyridine-3-carbonitrile

6,8-dichloro-2,7-naphthyridin-1(2H)-one

2,6-dihydroxy-3-cyano-4-methylpyrimidine

Refernces

• 1、 -. "Inhibiting WNT signal conduction of compound, composition and use thereof (by machine translation)". . . Retrieved 2017/12/27.
• 2、 -. "Compound as WNT Signaling Inhibitor, Composition, and Use Thereof". . . Retrieved 2015/05/05.