Nampt-IN-1

Base Information

• Chemical Name: Nampt-IN-1
• CAS No.: 1698878-14-6
• Molecular Formula: C20H25N3O5S
• Molecular Weight: 419.49
• Mol file: 1698878-14-6.mol

Synonyms:Nampt-IN-1;2-hydroxy-2-methyl-N-(2-(2-(pyridin-3-yloxy)acetyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)propane-1-sulfonamide;2-Hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-1-propanesulfonamide

Chemical Property of Nampt-IN-1

Chemical Property:

• Boiling Point: 659.9±65.0 °C(Predicted)
• PKA: 8.67±0.20(Predicted)
• PSA: 117.21000
• Density: 1.363±0.06 g/cm3(Predicted)
• LogP: 2.64960
• Storage Temp.: 2-8°C

Purity/Quality:

99%+, ^*data from raw suppliers

Nampt-IN-1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Nampt-IN-1 is a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt; IC50 = 3.1 nM). It is selective for Nampt over a panel of greater than 100 human kinases at 1 μM. Nampt-IN-1 inhibits NAD+ formation in and proliferation of HCT116 cells (IC50s = 1.8 and 8.9 nM, respectively). It inhibits cell growth in a panel of cancer cell lines (IC50s = <0.2-2 μM). Nampt-IN-1 inhibits NAD+ formation in an A2780 ovarian carcinoma mouse xenograft model (ED50 = 2 mg/kg).
• Uses: Nampt-IN-1 functions as a co-drug. Nampt-IN-1 is a potent and selective NAMPT inhibitor.

Technology Process of Nampt-IN-1

There total 1 articles about Nampt-IN-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Pyridin-3-yloxy)-acetic acid (86649-57-2) + 2-hydroxy-2-methyl-N-( 1,2,3,4-tetrahydroisoquinolin-6-yl)propane-1-sulfonamidehydrochloride → 2-hydroxy-2-methyl-N-[2-[2-(3-pyridyloxy)acetyl]-3,4-dihydro-1H-isoquinolin-6-yl]propane-1-sulfonamide (1698878-14-6)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

upstream raw materials:

(Pyridin-3-yloxy)-acetic acid

Refernces