[6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER

Base Information

Chemical Name:[6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER
CAS No.:305371-16-8
Molecular Formula:C₁₃H₁₄FN₃O₃
Molecular Weight:279.271
Hs Code.:
Mol file:305371-16-8.mol

Synonyms:[6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER

Suppliers and Price of [6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
[6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER 95.00%
5MG
$ 505.42

Total 3 raw suppliers

Chemical Property of [6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property:

Boiling Point:411.0±45.0 °C(Predicted)
PKA:5.00±0.16(Predicted)
PSA：92.08000
Density:1.285±0.06 g/cm3(Predicted)
LogP:2.73708

Purity/Quality:

97% ^*data from raw suppliers

[6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of [6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER

There total 7 articles about [6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-05-8,26809-02-9
acetonitrile

: 305371-15-7
5-tert-butoxycarbonylamino-2-fluoro-isonicotinic acid, methyl ester

: 305371-16-8
[6-fluoro-4-(3-nitrilo-propionyl)-pyridin-3-yl]-carbamic acid, tert-butyl ester

Guidance literature:: acetonitrile; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

5-tert-butoxycarbonylamino-2-fluoro-isonicotinic acid, methyl ester; With acetic acid; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/j.bmcl.2004.01.034

Reference yield:

: 305371-42-0
5-tert-butoxycarbonylamino-2-chloro-isonicotinic acid, methyl ester

: 75-05-8,26809-02-9
acetonitrile

: 305371-16-8
[6-fluoro-4-(3-nitrilo-propionyl)-pyridin-3-yl]-carbamic acid, tert-butyl ester

Guidance literature:: With n-butyllithium; In tetrahydrofuran; methanol; hexane; at -78 ℃; for 1.5h;

Reference yield:

: 456-24-6
2-Fluoro-5-nitropyridine

: 305371-16-8
[6-fluoro-4-(3-nitrilo-propionyl)-pyridin-3-yl]-carbamic acid, tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 70 percent / H₂ / Raney Ni / ethyl acetate

2.1: 96 percent / 2-methyl-propan-2-ol / 4 h / 40 °C

3.1: n-BuLi; tetramethylethylenediamine / diethyl ether / -78 °C

3.2: diethyl ether

4.1: methanol; CHCl₃; hexane / 2 h / 0 - 20 °C

5.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C

5.2: AcOH / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen; nickel; In tetrahydrofuran; methanol; diethyl ether; hexane; chloroform; ethyl acetate; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2004.01.034