5-(tert-butoxycarbonylamino)-2-chloropyridin-4-ylboronic acid

Base Information

• Chemical Name: 5-(tert-butoxycarbonylamino)-2-chloropyridin-4-ylboronic acid
• CAS No.: 1006689-23-1
• Molecular Formula: C10H14BClN2O4
• Molecular Weight: 286.523
• Hs Code.: 2933399090
• Mol file: 1006689-23-1.mol

Synonyms:5-(tert-butoxycarbonylamino)-2-chloropyridin-4-ylboronic acid

Chemical Property of 5-(tert-butoxycarbonylamino)-2-chloropyridin-4-ylboronic acid

Chemical Property:

• PSA: 95.17000
• LogP: 0.77540
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

(5-((tert-Butoxycarbonyl)amino)-2-chloropyridin-4-yl)boronicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(tert-butoxycarbonylamino)-2-chloropyridin-4-ylboronic acid

There total 1 articles about 5-(tert-butoxycarbonylamino)-2-chloropyridin-4-ylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Triisopropyl borate (5419-55-6) → (5-{[(tert-butoxycarbonyl)amino]methyl}-2-chloropyridin-4yl)boronic acid (1006689-23-1)

Guidance literature:

(6-chloropyridin-3-ylmethyl)carbamic acid tert-butyl ester; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 - -77 ℃; for 0.166667h;

Triisopropyl borate; In tetrahydrofuran; pentane; at -20 - 20 ℃;

With hydrogenchloride; water; In tetrahydrofuran; pentane; at 0 ℃;

Reference yield: 24.0%

(5-{[(tert-butoxycarbonyl)amino]methyl}-2-chloropyridin-4yl)boronic acid (1006689-23-1) → tert-butyl({6-chloro-4-[4-chloro-2-(2,6-difluorobenzoyl)phenyl]pyridin-3-yl}methyl)carbamate (1006689-24-2)

Guidance literature:

(5-chloro-2-iodophenyl)(2,6-difluorophenyl)methanone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; for 0.25h;

(5-{[(tert-butoxycarbonyl)amino]methyl}-2-chloropyridin-4yl)boronic acid; With sodium carbonate; In 1,2-dimethoxyethane; water; for 5h; Heating / reflux;

upstream raw materials:

Triisopropyl borate

Downstream raw materials:

tert-butyl({6-chloro-4-[4-chloro-2-(2,6-difluorobenzoyl)phenyl]pyridin-3-yl}methyl)carbamate

Refernces