((R)-4,4-dimethylpyrrolidin-2-yl)methanol

Base Information

• Chemical Name: ((R)-4,4-dimethylpyrrolidin-2-yl)methanol
• CAS No.: 1610034-33-7
• Molecular Formula: C7H15NO
• Molecular Weight: 129.2
• Mol file: 1610034-33-7.mol

Synonyms:((R)-4,4-dimethylpyrrolidin-2-yl)methanol

Chemical Property of ((R)-4,4-dimethylpyrrolidin-2-yl)methanol

Chemical Property:

• Boiling Point: 187.9±13.0 °C(Predicted)
• PKA: 14.77±0.10(Predicted)
• PSA: 32.26000
• Density: 0.911±0.06 g/cm3(Predicted)
• LogP: 0.69560
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

NLT 98% ^*data from raw suppliers

(R)-(4,4-dimethylpyrrolidin-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ((R)-4,4-dimethylpyrrolidin-2-yl)methanol

There total 4 articles about ((R)-4,4-dimethylpyrrolidin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(R)-5-(hydroxymethyl)-3,3-dimethylpyrrolidin-2-one (493035-98-6) → (R)-(4,4-dimethylpyrrolidin-2-yl)methanol (1610034-33-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; Reflux;

Reference yield:

(7aR)-3,3-dimethyltetrahydro-5H-pyrrolo[1,2-c][1,3]oxazol-5-one → (R)-(4,4-dimethylpyrrolidin-2-yl)methanol (1610034-33-7)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / -78 - 20 °C

2: toluene-4-sulfonic acid / methanol / 2 h / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Reflux

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; n-heptane; ethylbenzene;

Reference yield:

(R)-5-hydroxymethylpyrrolidin-2-one (66673-40-3) → (R)-(4,4-dimethylpyrrolidin-2-yl)methanol (1610034-33-7)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene / 1.5 h / Dean-Stark; Reflux

2: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / -78 - 20 °C

3: toluene-4-sulfonic acid / methanol / 2 h / Reflux

4: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Reflux

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; n-heptane; ethylbenzene; toluene;

upstream raw materials:

(R)-5-(hydroxymethyl)-3,3-dimethylpyrrolidin-2-one

(R)-5-hydroxymethylpyrrolidin-2-one

(R)-3,3,6,6-tetramethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one

Refernces

• 1、 -. "PYRROLIDINE GPR40 MODULATORS". Paragraph 00292. . Retrieved 2014/06/11.