ortho-Phosphate

Base Information

• Chemical Name: ortho-Phosphate
• CAS No.: 11-36-9
• Molecular Weight: 0
• Mol file: 11-36-9.mol

Synonyms:

Chemical Property of ortho-Phosphate

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Refernces

A Cascade Reaction of Michael Addition and Truce-Smiles Rearrangement to Synthesize Trisubstituted 4-Quinolone Derivatives

10.1021/acs.joc.0c01662

Caixia Xie, Di Yang, Xinfeng Wang, and Chen Ma present a novel transition-metal-free cascade reaction for synthesizing 4-quinolone derivatives. The method involves Michael addition and Truce-Smiles rearrangement, yielding a broad scope of 4-quinolones in moderate-to-excellent yields under mild conditions. The study explores the optimization of reaction conditions, substrate scope, and scalability, demonstrating the potential for synthesizing densely functionalized 4-quinolone derivatives with applications in biomedical research. The use of sulfonamides through Truce-Smiles rearrangement offers a new approach to constructing heterocyclic compounds, with ongoing research focusing on applying this strategy to synthesize bioactive heterocyclic compounds.

Synthesis of 3-substituted-4-hydroxyquinoline N-oxides from the Baylis-Hillman adducts of o-nitrobenzaldehydes

10.1016/S0040-4020(02)01518-1

The study focuses on the synthesis of 3-substituted-4-hydroxyquinoline N-oxides from Baylis–Hillman adducts derived from o-nitrobenzaldehydes. The key chemicals used in the study include trifluoroacetic acid, trifllic acid, and various Baylis–Hillman adducts such as 1b–f, which are derived from methyl vinyl ketone, phenyl vinyl sulfone, and ethyl acrylate. These chemicals serve the purpose of facilitating the reaction that yields the desired quinoline N-oxide derivatives. The study also explores the reaction mechanism, suggesting that N-hydroxyisoxazoline acts as a key intermediate in the process. The use of triflic acid was found to increase the acidity of the reaction medium, which was crucial for obtaining the quinoline N-oxides in reasonable yields. The study provides experimental evidence supporting the proposed reaction mechanism and successfully synthesizes several 3-substituted-4-hydroxyquinoline N-oxides, which are valuable synthetic intermediates.