8-PCPT-CGMP, TEA

Base Information

• Chemical Name: 8-PCPT-CGMP, TEA
• CAS No.: 54364-02-2
• Molecular Formula: C16H15 Cl N5 O7 P S
• Molecular Weight: 487.817
• Mol file: 54364-02-2.mol

Synonyms:4H-Furo[3,2-d]-1,3,2-dioxaphosphorin,guanosine deriv.; 8-(4-Chlorophenylthio)-cGMP; 8-(p-Chlorophenylthio)-cGMP

Chemical Property of 8-PCPT-CGMP, TEA

Chemical Property:

• Vapor Pressure: 4.28E-30mmHg at 25°C
• Boiling Point: 841.8°C at 760 mmHg
• Flash Point: 462.9°C
• PSA: 213.16000
• Density: 2.19g/cm³
• LogP: 3.20980

Purity/Quality:

97% ^*data from raw suppliers

8-Pcpt-cGMP ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 8-Pcpt-cGMP is an activator of protein kinase.

Technology Process of 8-PCPT-CGMP, TEA

There total 1 articles about 8-PCPT-CGMP, TEA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 8-(4-chlorophenylthio)guanosine-3′,5′-cyclic monophosphate (54364-02-2)

Guidance literature:

8-Bromguanosin, p-Chlorphenylthiol, Na-acetat;

Reference yield: 61.0%

8-(4-chlorophenylthio)guanosine-3′,5′-cyclic monophosphate (54364-02-2) + PVS (5535-48-8) → 2-amino-9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-8-[(4-chlorophenyl)thio]-1-[2-(phenylsulfonyl)ethyl]-1,9-dihydro-6H-purin-6-one

Guidance literature:

With sodium phosphate; In methanol; at 37 ℃; for 20h; pH=7.9;

DOI:10.1021/jm0702581

Reference yield: 29.0%

8-(4-chlorophenylthio)guanosine-3′,5′-cyclic monophosphate (54364-02-2) → 8-(4-chlorophenylsulfonyl)guanosine-3',5'-cyclic monophosphate

Guidance literature:

With Oxone; In methanol;

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