Hydroxyamphetamine

Base Information

• Chemical Name: Hydroxyamphetamine
• CAS No.: 1518-86-1
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.208
• Mol file: 1518-86-1.mol

Synonyms:Hydroxyamphetamine;4-hydroxyamphetamine;Paredrinex;Pulsoton;α-Methyramine;4-(2-azanylpropyl)phenol

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Chemical Property of Hydroxyamphetamine

Chemical Property:

• Vapor Pressure: 0.0024mmHg at 25°C
• Melting Point: 125-126°
• Refractive Index: 1.5270 (estimate)
• Boiling Point: 279.2°C at 760 mmHg
• PKA: pKa 9.6 (Uncertain)
• Flash Point: 122.7°C
• PSA: 32.26000
• Density: 1.07g/cm³
• LogP: 1.98730

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hydroxyamphetamine

There total 40 articles about Hydroxyamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(4-benzyloxy-phenyl)-1-methyl-ethylamine (7176-39-8,71488-45-4) → p-hydroxyamphetamine (103-86-6,1518-86-1)

Guidance literature:

With palladium on activated carbon; hydrogen; In methanol; at 20 ℃; for 18h; Sealed tube;

DOI:10.1002/anie.201806490

Reference yield: 94.0%

1-(4-hydroxyphenyl)propan-2-one oxime → p-hydroxyamphetamine (103-86-6,1518-86-1)

Guidance literature:

With ammonium formate; zinc; In methanol; for 0.05h; Heating;

Reference yield: 88.0%

4-methoxyphenylacetone (770-39-8) → p-hydroxyamphetamine (103-86-6,1518-86-1)

Guidance literature:

With ammonia; hydrogen; In tetrahydrofuran; at 120 ℃; for 15h;

DOI:10.1126/science.aan6245

upstream raw materials:

2-amino-1-(4-methyoxyphenyl)propane

(+/-)-4-(2-amino-propyl)-aniline

2-amino-3-(4-hydroxy-phenyl)-2-methyl-propionic acid

2-amino-1-phenylpropane

Downstream raw materials:

(2,6-Dichloro-4-{1-hydroxy-2-[2-(4-hydroxy-phenyl)-1-methyl-ethylamino]-ethyl}-phenyl)-carbamic acid ethyl ester

4-(2-(benzylamino)propyl)phenol

C₁₉H₂₅N₃O₂

C₁₈H₃₀N₂O₂

Refernces

• 1、 -. "INDOLE AHR INHIBITORS AND USES THEREOF". Paragraph 00657; 00660. . Retrieved 2018/11/22.
• 2、 -. "Improved synthetic method of (R)-1-aryl-2-propylamine". Paragraph 0035; 0036; 0038; 0049. . Retrieved 2018/07/30.