1,3,5(10)-ESTRATRIEN-2,3-DIOL-17-ONE 3-METHYL ETHER

Base Information

• Chemical Name: 1,3,5(10)-ESTRATRIEN-2,3-DIOL-17-ONE 3-METHYL ETHER
• CAS No.: 5976-63-6
• Molecular Formula: C19H24O3
• Molecular Weight: 300.398
• Mol file: 5976-63-6.mol

Synonyms:1,3,5(10)-ESTRATRIEN-2,3-DIOL-17-ONE 3-METHYL ETHER;2-HYDROXYESTRONE-3-METHYL ETHER;2-Hydroxy-3-methoxy-1,3,5(10)-estratriene-17-one;2-Hydroxy-3-methoxyestra-1(10),2,4-triene-17-one;2-Hydroxy-3-methoxyestra-1,3,5(10)-trien-17-one;3-Methoxy-2-hydroxyestra-1(10),2,4-triene-17-one

Chemical Property of 1,3,5(10)-ESTRATRIEN-2,3-DIOL-17-ONE 3-METHYL ETHER

Chemical Property:

• Boiling Point: 463.5±45.0 °C(Predicted)
• PKA: 10.32±0.40(Predicted)
• PSA: 46.53000
• Density: 1.172±0.06 g/cm3(Predicted)
• LogP: 3.82600

Purity/Quality:

98% ^*data from raw suppliers

2-Hydroxyestrone-3-methylEther ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3,5(10)-ESTRATRIEN-2,3-DIOL-17-ONE 3-METHYL ETHER

There total 4 articles about 1,3,5(10)-ESTRATRIEN-2,3-DIOL-17-ONE 3-METHYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

estrone 3-methyl ether (1624-62-0) → 3-methoxy-4-hydroxy-1,3,5 (10)-estratrien-17-one (5976-62-5) + 2-Hydroxyestrone 3-methyl ether (5976-63-6)

Guidance literature:

3-methoxy-13β-methylgona-1,3,5(10)-trien-17-one; With spiro[bicyclo[2.2.1]heptane-2,4′-[1,2]dioxolane]-3′,5′-dione; at 40 ℃; Sealed tube;

With methylamine; In ethanol; at 25 ℃;

DOI:10.1021/acs.joc.8b01392

Reference yield:

Estrone 2,3-dimethyl ether (5976-64-7) → 2-methoxyestrone (362-08-3,7683-30-9) + 2-Hydroxyestrone 3-methyl ether (5976-63-6)

Guidance literature:

With boron tribromide; In dichloromethane; at 30 ℃;

DOI:10.1248/cpb.31.3309

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-hydroxyestrone (362-06-1,4735-38-0) → 2-methoxyestrone (362-08-3,7683-30-9) + 2-Hydroxyestrone 3-methyl ether (5976-63-6) + Estrone 2,3-dimethyl ether (5976-64-7)

Guidance literature:

In methanol; diethyl ether; at 30 ℃; Rate constant;

DOI:10.1248/cpb.31.3309

upstream raw materials:

diazomethane

2-hydroxyestrone

Estrone 2,3-dimethyl ether

3,4-Dimethoxy-1,3,5⁽¹⁰⁾-estratrien-17-one

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