5-CHLORO-2-P-TOLYL-1H-INDOLE

Base Information

• Chemical Name: 5-CHLORO-2-P-TOLYL-1H-INDOLE
• CAS No.: 66866-07-7
• Molecular Formula: C15H12ClN
• Molecular Weight: 241.72
• Mol file: 66866-07-7.mol

Synonyms:5-CHLORO-2-P-TOLYL-1H-INDOLE

Chemical Property of 5-CHLORO-2-P-TOLYL-1H-INDOLE

Chemical Property:

• PSA: 15.79000
• LogP: 4.79670
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-2-(p-tolyl)-1H-indole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLORO-2-P-TOLYL-1H-INDOLE

There total 10 articles about 5-CHLORO-2-P-TOLYL-1H-INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-[(4-chlorophenyl)amino]-1-(4-methylphenyl)ethan-1-one (60532-54-9) + 4-chloro-aniline (106-47-8) → 2-(4-methylphenyl)-5-chloro-1H-indole (66866-07-7)

Guidance literature:

2-[(4-chlorophenyl)amino]-1-(4-methylphenyl)ethan-1-one; 4-chloro-aniline; With triphenylphosphine; palladium(II) bromide; In 2,2,2-trifluoroethanol; toluene; for 0.25h; Schlenk technique; Inert atmosphere;

With hydrogen; sodium sulfate; In 2,2,2-trifluoroethanol; toluene; at 150 ℃; for 24h; under 41372.9 Torr; regioselective reaction; Autoclave; Schlenk technique;

DOI:10.1002/ejoc.201900394

Reference yield: 93.0%

4-chloro-2-(p-tolylethynyl)aniline (1037493-25-6) → 2-(4-methylphenyl)-5-chloro-1H-indole (66866-07-7)

Guidance literature:

With Au/Carbon G-60 catalyst; In toluene; at 90 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201305579

Reference yield: 75.0%

4-tolyl iodide (624-31-7) + 5-chloro-1H-indole (17422-32-1) → 2-(4-methylphenyl)-5-chloro-1H-indole (66866-07-7)

Guidance literature:

With C₁₈H₁₆N₂O₄Pd; potassium acetate; In water; at 100 ℃; for 16h;

DOI:10.1080/00397911.2017.1381260

upstream raw materials:

C₁₅H₁₀ClNO₂

p-chloro-o-iodoaniline

4-n-methylphenylacetylene

4-chloro-2-(p-tolylethynyl)aniline