3-(Furan-2-yl)-3-phenylpropan-1-amine

Base Information

• Chemical Name: 3-(Furan-2-yl)-3-phenylpropan-1-amine
• CAS No.: 374910-04-0
• Molecular Formula: C13H15NO
• Molecular Weight: 201.26
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID00389887
• Nikkaji Number: J3.369.066E
• Mol file: 374910-04-0.mol

Synonyms:374910-04-0;3-(furan-2-yl)-3-phenylpropan-1-amine;3-Furan-2-yl-3-phenyl-propylamine;3-(2-FURYL)-3-PHENYLPROPAN-1-AMINE;ImprimatinB2;2-(3-amino-1-phenylpropyl)furan;ChemDiv2_000840;Cambridge id 6956001;Oprea1_337849;SCHEMBL15829149;DTXSID00389887;HMS1371G04;BBL036711;MFCD02235141;STL559090;AKOS000549072;AKOS022184523;3-(2-Furyl)-3-phenyl-1-propanamine;BS-37552;CS-0323327;EU-0043141;3-(2-Furyl)-3-phenylpropan-1-amine, AldrichCPR;SR-01000477579;A1-39777;SR-01000477579-1

Chemical Property of 3-(Furan-2-yl)-3-phenylpropan-1-amine

Chemical Property:

• Vapor Pressure: 0.00281mmHg at 25°C
• Boiling Point: 285.4°C at 760 mmHg
• Flash Point: 126.4°C
• PSA: 39.16000
• Density: 1.064g/cm³
• LogP: 3.46060
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 201.115364102
• Heavy Atom Count: 15
• Complexity: 177

Purity/Quality:

99% ^*data from raw suppliers

3-(2-Furyl)-3-phenylpropan-1-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 36-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(CCN)C2=CC=CO2

Technology Process of 3-(Furan-2-yl)-3-phenylpropan-1-amine

There total 4 articles about 3-(Furan-2-yl)-3-phenylpropan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-(3-amino-1-phenylpropyl)furan (374910-04-0)

Guidance literature:

With methanol; ammonia; nickel; at 65 ℃; Hydrierung unter Druck;

Reference yield:

furfural (98-01-1) → 2-(3-amino-1-phenylpropyl)furan (374910-04-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 95 percent / ammonium acetate / benzene / 10 h / Heating

2.1: Mg / diethyl ether / Heating

2.2: 87 percent / benzene; diethyl ether / 1.5 h / 42 - 44 °C

3.1: 52 percent / KOH / ethane-1,2-diol / 3 h / Heating

4.1: 85 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

With ammonium acetate; potassium hydroxide; lithium aluminium tetrahydride; magnesium; In diethyl ether; ethylene glycol; benzene;

DOI:10.1007/s10593-005-0166-8

Reference yield:

ethyl (E)-2-cyano-3-(2-furyl)-2-propenoate (67449-75-6,23973-22-0) → 2-(3-amino-1-phenylpropyl)furan (374910-04-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Mg / diethyl ether / Heating

1.2: 87 percent / benzene; diethyl ether / 1.5 h / 42 - 44 °C

2.1: 52 percent / KOH / ethane-1,2-diol / 3 h / Heating

3.1: 85 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

With potassium hydroxide; lithium aluminium tetrahydride; magnesium; In diethyl ether; ethylene glycol;

DOI:10.1007/s10593-005-0166-8

upstream raw materials:

furfural

ethyl (E)-2-cyano-3-(2-furyl)-2-propenoate

ethyl α-cyano-β-(2-furyl)hydrocinnamate

Downstream raw materials:

(2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

C₂₈H₃₉NO₆

furan-2-ylmethyl-(3-furan-2-yl-3-phenyl-propyl)-amine