1-(2,3-anhydro-beta-D-glycero-pentofuranosyl)-4-(methylamino)pyrimidin-2(1H)-one

Base Information

• Chemical Name: 1-(2,3-anhydro-beta-D-glycero-pentofuranosyl)-4-(methylamino)pyrimidin-2(1H)-one
• CAS No.: 114563-61-0
• Molecular Formula: C₁₀H₁₃N₃O₄
• Molecular Weight: 239.231
• Mol file: 114563-61-0.mol

Synonyms:3,6-Dioxabicyclo[3.1.0]hexane,2(1H)-pyrimidinone deriv.

Chemical Property of 1-(2,3-anhydro-beta-D-glycero-pentofuranosyl)-4-(methylamino)pyrimidin-2(1H)-one

Chemical Property:

• Vapor Pressure: 6.68E-09mmHg at 25°C
• Boiling Point: 422.3°Cat760mmHg
• Flash Point: 209.2°C
• Density: 1.77g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,3-anhydro-beta-D-glycero-pentofuranosyl)-4-(methylamino)pyrimidin-2(1H)-one

There total 6 articles about 1-(2,3-anhydro-beta-D-glycero-pentofuranosyl)-4-(methylamino)pyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-{(1S,2R,4R,5S)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,6-dioxa-bicyclo[3.1.0]hex-2-yl}-4-methylamino-1H-pyrimidin-2-one → 1-(2,3-anhydro-β-D-lyxofuranosyl)-4-(methylamino)-2(1H)-pyrimidinone (114563-61-0)

Guidance literature:

With acetic acid; at 22 ℃; for 0.5h; Yield given;

DOI:10.1021/jm00402a038

Reference yield:

2’,3’-anhydro-5’-O-(4,4’-dimethoxytrityl)-1-β-D-lyxofuranosyl-uracil (114551-07-4) → 1-(2,3-anhydro-β-D-lyxofuranosyl)-4-(methylamino)-2(1H)-pyrimidinone (114563-61-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) POCl₃, 2.) Et₃N / 1) CH₃CN, 20 deg C; 2) CH₃CN, 20 deg C, 1 h

2: dioxane / 1.5 h / 20 °C

3: aq. AcOH / 0.5 h / 22 °C

With acetic acid; triethylamine; trichlorophosphate; In 1,4-dioxane;

DOI:10.1021/jm00402a038

Reference yield:

1-{(1S,2R,4R,5S)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,6-dioxa-bicyclo[3.1.0]hex-2-yl}-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one (114551-10-9) → 1-(2,3-anhydro-β-D-lyxofuranosyl)-4-(methylamino)-2(1H)-pyrimidinone (114563-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dioxane / 1.5 h / 20 °C

2: aq. AcOH / 0.5 h / 22 °C

With acetic acid; In 1,4-dioxane;

DOI:10.1021/jm00402a038

upstream raw materials:

2’,3’-anhydro-5’-O-(4,4’-dimethoxytrityl)-1-β-D-lyxofuranosyl-uracil

1-{(1S,2R,4R,5S)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,6-dioxa-bicyclo[3.1.0]hex-2-yl}-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one

2’,3’-di-O-(methanesulfonyl)-5’-O-(4,4’-dimethoxytrityl)-uridine

5'-dimethoxytrityluridine