(1S,3aR)-1β,7-Dimethoxy-4β-(3-methoxy-4-hydroxyphenyl)-1,3,3aβ,4,9,9aα-hexahydronaphtho[2,3-c]furan-6-ol

Base Information

• Chemical Name: (1S,3aR)-1β,7-Dimethoxy-4β-(3-methoxy-4-hydroxyphenyl)-1,3,3aβ,4,9,9aα-hexahydronaphtho[2,3-c]furan-6-ol
• CAS No.: 101312-79-2
• Molecular Formula: C₂₁H₂₄O₆
• Molecular Weight: 372.418
• Mol file: 101312-79-2.mol

Synonyms:Naphtho[2,3-c]furan-6-ol,1,3,3a,4,9,9a-hexahydro-4-(4-hydroxy-3-methoxyphenyl)-1,7-dimethoxy-, [1S-(1a,3aa,4a,9ab)]-; Formosanol; Tsugacetal

Chemical Property of (1S,3aR)-1β,7-Dimethoxy-4β-(3-methoxy-4-hydroxyphenyl)-1,3,3aβ,4,9,9aα-hexahydronaphtho[2,3-c]furan-6-ol

Chemical Property:

• PSA: 77.38000
• LogP: 3.03810

Purity/Quality:

98%min ^*data from raw suppliers

Formosanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S,3aR)-1β,7-Dimethoxy-4β-(3-methoxy-4-hydroxyphenyl)-1,3,3aβ,4,9,9aα-hexahydronaphtho[2,3-c]furan-6-ol

There total 22 articles about (1S,3aR)-1β,7-Dimethoxy-4β-(3-methoxy-4-hydroxyphenyl)-1,3,3aβ,4,9,9aα-hexahydronaphtho[2,3-c]furan-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

O-dibenzyl methyl-(+/-)-β-conidendral (105783-68-4,105817-24-1) → methyl-(+/-)-β-conidendral (71724-99-7,71772-19-5,101312-79-2,105817-21-8,105817-25-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.1016/S0040-4020(01)87617-1

Reference yield: 70.0%

O-dibenzyl methyl epi-1-(+/-)-α-conidendral (105783-68-4,105817-24-1) → methyl epi-1-(+/-)-α-conidendral (71724-99-7,71772-19-5,101312-79-2,105817-21-8,105817-25-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; under 2250.2 Torr; Ambient temperature;

DOI:10.1016/S0040-4020(01)87617-1

Reference yield: 19.0%

α-intermedianol → (1S,3aR,4S,9aR)-1,7-dimethoxy-4-(4'-hydroxy-3'-methoxyphenyl)-1,3,3a,4,9,9a-hexahydronaphtho<2,3-c>furan-6-ol (101312-79-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 24h; Ambient temperature;

upstream raw materials:

(1R,3aR,4S,9aR)-1,7-dimethoxy-4-(4'-hydroxy-3'-methoxyphenyl)-1,3,3a,4,9,9a-hexahydronaphtho<2,3-c>furan-6-ol

O-dibenzyl methyl epi-1-(+/-)-α-conidendral

1-(benzyloxy)-4-(bromomethyl)-2-methoxybenzene

2-(4-benzyloxy-3-methoxyphenyl)-1,3-dithiane

Downstream raw materials:

O-diacetyl methyl epi-1-(+/-)-α-conidendral

O-diacetyl methyl-(+/-)-β-conidendral

(1S,3aR,4S,9aR)-4-(3,4-Dimethoxy-phenyl)-1,6,7-trimethoxy-1,3,3a,4,9,9a-hexahydro-naphtho[2,3-c]furan

Acetic acid 4-(4-acetoxy-3-methoxy-phenyl)-7-methoxy-1-oxo-1,3-dihydro-naphtho[2,3-c]furan-6-yl ester

Refernces

• 1、 Cambie, Richard C.,Clark, George R.,Craw, Peter A.,Jones, Tony C.,Rutledge, Peter S.,Woodgate, Paul D.. "Chemistry of the Podocarpaceae. LXIX. Further Lignans from the Wood of Dacrydium intermedium". . p. 1631 - 1645. Retrieved 2007/10/02.