1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone

Base Information

• Chemical Name: 1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone
• CAS No.: 645419-13-2
• Molecular Formula: C₁₂H₁₄N₂O
• Molecular Weight: 202.256
• Hs Code.: 2933990090
• Mol file: 645419-13-2.mol

Synonyms:1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone

Chemical Property of 1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone

Chemical Property:

• Boiling Point: 488.1±45.0 °C(Predicted)
• PKA: 4.06±0.20(Predicted)
• Flash Point: 249oC
• PSA: 46.33000
• Density: 1.27±0.1 g/cm3(Predicted)
• LogP: 2.31310
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

1-(6''-Aminospiro[cyclopropane-1,3''-indolin]-1''-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone

There total 3 articles about 1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-acetyl-6-nitro-1,2-dihydro-3-spiro-1'-cyclopropyl-1H-indole (645419-12-1) → 1-Acetyl-6-amino-1,2-dihydro-3-spiro-1'-cyclopropyl-1H-indole (645419-13-2)

Guidance literature:

With hydrogenchloride; Pd-C; In methanol; ethanol;

Reference yield:

1',2'-dihydrospiroindole> (174-66-3) → 1-Acetyl-6-amino-1,2-dihydro-3-spiro-1'-cyclopropyl-1H-indole (645419-13-2)

Guidance literature:

Multi-step reaction with 3 steps

1: NaNO₃ / sulfuric acid

2: sodium hydrogencarbonate / dichloromethane

3: hydrogenchloride / Pd-C / methanol; ethanol

With hydrogenchloride; NaNO₃; sodium hydrogencarbonate; Pd-C; In methanol; ethanol; dichloromethane; sulfuric acid;

Reference yield:

6-nitro-1,2-dihydro-3-spiro-1'-cyclopropyl-1H-indole (618446-19-8) → 1-Acetyl-6-amino-1,2-dihydro-3-spiro-1'-cyclopropyl-1H-indole (645419-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane

2: hydrogenchloride / Pd-C / methanol; ethanol

With hydrogenchloride; sodium hydrogencarbonate; Pd-C; In methanol; ethanol; dichloromethane;

upstream raw materials:

1-acetyl-6-nitro-1,2-dihydro-3-spiro-1'-cyclopropyl-1H-indole

1',2'-dihydrospiroindole>

6-nitro-1,2-dihydro-3-spiro-1'-cyclopropyl-1H-indole

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