BOC,BZL-D-ALA-OH

Base Information

• Chemical Name: BOC,BZL-D-ALA-OH
• CAS No.: 120571-59-7
• Molecular Formula: C15H21NO4
• Molecular Weight: 293.363
• Hs Code.: 2924299090
• Mol file: 120571-59-7.mol

Synonyms:BOC,BZL-D-ALA-OH;N-TERT-BUTYLOXYCARBONYL-N-BENZYL-D-ALANINE

Chemical Property of BOC,BZL-D-ALA-OH

Chemical Property:

• Boiling Point: 383.3±31.0 °C(Predicted)
• PKA: -1.68±0.70(Predicted)
• PSA: 55.84000
• Density: 1.090±0.06 g/cm3(Predicted)
• LogP: 2.98520

Purity/Quality:

98% ^*data from raw suppliers

Boc,Bzl-D-Ala-OH ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC,BZL-D-ALA-OH

There total 1 articles about BOC,BZL-D-ALA-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

di-tert-butyl dicarbonate (24424-99-5) + N-benzyl D-alanine methyl ester (120571-58-6) → N-benzyl-N-(tert-butoxycarbonyl)-D-alanine methyl ester (120571-59-7)

Guidance literature:

With dmap; In acetonitrile; 1.) RT, 1 h, 2.) reflux, 1 h;

DOI:10.1021/jo00276a053

Reference yield: 80.0%

N-benzyl-N-(tert-butoxycarbonyl)-D-alanine methyl ester (120571-59-7) → N-benzyl-N-(tert-butoxycarbonyl)-D-alaninal (120205-98-3)

Guidance literature:

With diisobutylaluminium hydride; In diethyl ether; toluene; at -78 ℃; for 0.5h;

DOI:10.1021/jo00276a053

Reference yield:

N-benzyl-N-(tert-butoxycarbonyl)-D-alanine methyl ester (120571-59-7) → Benzyl-[1-(6-methoxy-tetrahydro-pyran-2-yl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: DIBAL / diethyl ether / -78 °C

2: 2.) PPTS / 1.) Eu(fod)3 / 1.) Et₂O, 50 deg C, 15 kbar, 2.) MeOH, room temp;

3: H₂ / Pd/C / ethyl acetate / Ambient temperature

With hydrogen; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; palladium on activated charcoal; Eu(fod)3; In diethyl ether; ethyl acetate;

DOI:10.1016/S0040-4039(00)82244-3

upstream raw materials:

di-tert-butyl dicarbonate

N-benzyl D-alanine methyl ester

Downstream raw materials:

N-benzyl-N-(tert-butoxycarbonyl)-D-alaninal

Benzyl-[1-(6-methoxy-3,6-dihydro-2H-pyran-2-yl)-ethyl]-carbamic acid tert-butyl ester

Benzyl-[(R)-1-((2S,5S,6S)-5-hydroxy-6-methoxy-tetrahydro-pyran-2-yl)-ethyl]-carbamic acid tert-butyl ester

Benzyl-[(R)-1-((2R,5S,6R)-5-hydroxy-6-methoxy-tetrahydro-pyran-2-yl)-ethyl]-carbamic acid tert-butyl ester