(S)-6-METHYL-PIPERAZIN-2-ONE

Base Information

• Chemical Name: (S)-6-METHYL-PIPERAZIN-2-ONE
• CAS No.: 323592-68-3
• Molecular Formula: C₅H₁₀N₂O
• Molecular Weight: 114.147
• Mol file: 323592-68-3.mol

Synonyms:(S)-6-METHYL-PIPERAZIN-2-ONE;2-Piperazinone, 6-Methyl-, (6S)-;(6S)-6-methylpiperazin-2-one;(6S)-Methyl-piperazin-2-one

Chemical Property of (S)-6-METHYL-PIPERAZIN-2-ONE

Chemical Property:

• Boiling Point: 289.6±33.0 °C(Predicted)
• PKA: 15.53±0.40(Predicted)
• PSA: 41.13000
• Density: 0.992±0.06 g/cm3(Predicted)
• LogP: -0.24810
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-6-Methyl-piperazin-2-one 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-6-METHYL-PIPERAZIN-2-ONE

There total 2 articles about (S)-6-METHYL-PIPERAZIN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl (R)-3-(benzyloxycarbonylamino)-butanoate (142035-70-9) → 6-(S)-methylpiperazin-2-one (323592-68-3,1240589-57-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 24h;

Reference yield: 60.0%

1-benzyl-5-(S)-methyl-3-oxopiperazine (817553-85-8) → 6-(S)-methylpiperazin-2-one (323592-68-3,1240589-57-4)

Guidance literature:

1-benzyl-5-(S)-methyl-3-oxopiperazine; With carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine; In 1,1-dichloroethane; at 20 ℃;

In methanol; for 2h; Heating / reflux;

upstream raw materials:

1-benzyl-5-(S)-methyl-3-oxopiperazine

methyl (R)-3-(benzyloxycarbonylamino)-butanoate