Levomilnacipran hydrochloride

Base Information

• Chemical Name: Levomilnacipran hydrochloride
• CAS No.: 175131-60-9
• Molecular Formula: C15H23ClN2O
• Molecular Weight: 282.80892
• European Community (EC) Number: 620-477-4,807-579-6
• UNII: 371U2ZK31U
• DSSTox Substance ID: DTXSID801026201
• Wikidata: Q27256611
• NCI Thesaurus Code: C166646
• RXCUI: 1433211
• ChEMBL ID: CHEMBL2105732
• Mol file: 175131-60-9.mol

Synonyms:Fetzima;levomilnacipran;Levomilnacipran Hydrochloride

Chemical Property of Levomilnacipran hydrochloride

Chemical Property:

• PSA: 46.33000
• LogP: 3.27370
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 282.1498911
• Heavy Atom Count: 19
• Complexity: 295

Purity/Quality:

99% ^*data from raw suppliers

(1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamidehydrochloride 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCN(CC)C(=O)C1(CC1CN)C2=CC=CC=C2.Cl
• Isomeric SMILES: CCN(CC)C(=O)[C@]1(C[C@H]1CN)C2=CC=CC=C2.Cl
• Recent ClinicalTrials: Effect of F2695 on Brain Activity Measured by Functional Magnetic Resonance Imaging
• Recent EU Clinical Trials: A European Phase III, Multicentre, Double-blind, Randomised, Placebo-Controlled Monotherapy Study of Milnacipran for the Treatment of the Fibromyalgia Syndrome.
• Recent NIPH Clinical Trials: None
• Description: Levomilnacipran (Fetzima?) is a dual serotonin–norepinephrine reuptake inhibitor (SNRI) approved by the FDA in 2013 for the treatment of major depressive disorders (MDD). Levomilnacipran is the most active enantiomer of the racemate Milnacipran, which is currently used to treat pain associated with fibromyalgia. The drug was developed by Forest Laboratories and the Pierre Fabre group.
• Uses: The S-enatiomer of Milnacipran (M344600). The (1S-cis)-enatiomer of Milnacipran (M344600). The (1S-cis)-enatiomer of Milnacipran (M344600). A selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia.