(S)-1-(3,5-bis(trifluoroMethyl)phenyl)-3-(1-phenylethyl)thiourea

Base Information

• Chemical Name: (S)-1-(3,5-bis(trifluoroMethyl)phenyl)-3-(1-phenylethyl)thiourea
• CAS No.: 1445582-60-4
• Molecular Formula: C17H14F6N2S
• Molecular Weight: 392.3618792
• Mol file: 1445582-60-4.mol

Synonyms:(S)-1-(3,5-bis(trifluoroMethyl)phenyl)-3-(1-phenylethyl)thiourea;1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(cyclohexylamino)-1,2-diphenylethyl)thiourea

Chemical Property of (S)-1-(3,5-bis(trifluoroMethyl)phenyl)-3-(1-phenylethyl)thiourea

Chemical Property:

• PSA: 68.18000
• LogP: 9.27030

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-(3,5-bis(trifluoroMethyl)phenyl)-3-(1-phenylethyl)thiourea

There total 4 articles about (S)-1-(3,5-bis(trifluoroMethyl)phenyl)-3-(1-phenylethyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(1R,2R)-N1-cyclohexyl-1,2-diphenylethane-1,2-diamine (865980-96-7) + 3,5-bistrifluoromethylphenylisothiocyanate (23165-29-9) → 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(cyclohexylamino)-1,2-diphenylethyl)thiourea (1445582-60-4)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol4014975

Reference yield:

(R,R)-1,2-diphenylethylenediamine (35132-20-8) → 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(cyclohexylamino)-1,2-diphenylethyl)thiourea (1445582-60-4)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 20 °C / Inert atmosphere; Molecular sieve

2: sodium tetrahydroborate / methanol / 20 °C / Inert atmosphere

3: dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; In methanol; dichloromethane;

DOI:10.1021/ol4014975

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(cyclohexylamino)-1,2-diphenylethyl)thiourea (1445582-60-4)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 20 °C / Inert atmosphere; Molecular sieve

2: sodium tetrahydroborate / methanol / 20 °C / Inert atmosphere

3: dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; In methanol; dichloromethane;

DOI:10.1021/ol4014975

upstream raw materials:

(1R,2R)-N¹-cyclohexyl-1,2-diphenylethane-1,2-diamine

3,5-bistrifluoromethylphenylisothiocyanate

(R,R)-1,2-diphenylethylenediamine

cyclohexanone