(R)-3-Fluoropiperidine hy...

Base Information

• Chemical Name: (R)-3-Fluoropiperidine hy...
• CAS No.: 787564-37-8
• Molecular Formula: C5H11ClFN
• Molecular Weight: 139.6
• Mol file: 787564-37-8.mol

Synonyms:(R)-3-Fluoropiperidine hy...;(R)-3-Fluoropiperidine hydrochloride;(3R)-3-fluoropiperidine hydrochloride

Chemical Property of (R)-3-Fluoropiperidine hy...

Chemical Property:

• PSA: 12.03000
• LogP: 1.83870
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

95-99% ^*data from raw suppliers

(R)-3-FluoropiperidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-Fluoropiperidine hy...

There total 5 articles about (R)-3-Fluoropiperidine hy... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(3R)-3-fluoro-N-tosylpiperidine (1262236-64-5) → (3R)-3-fluoropiperidine hydrochloride (787564-37-8)

Guidance literature:

(3R)-3-fluoro-N-tosylpiperidine; With magnesium; In methanol; at 10 - 20 ℃; for 3h; Schlenk technique; Inert atmosphere; Sonication;

With hydrogenchloride; In diethyl ether; pH=Ca. 1;

DOI:10.1002/anie.201913100

Reference yield: 30.0%

(R)-1-benzyl-3-fluoro-piperidine (873221-82-0) + (S)-N-benzyl-2-fluoromethylpyrrolidine (787564-48-1) → (3R)-3-fluoropiperidine hydrochloride (787564-37-8)

Guidance literature:

With carbonochloridic acid 1-chloro-ethyl ester; In methanol; dichloromethane; at 20 ℃; for 2.25h; Product distribution / selectivity; Heating / reflux;

Reference yield:

(3R)-3-Fluoropiperidine-1-carboxylic acid tert-butyl ester (873221-81-9) → (3R)-3-fluoropiperidine hydrochloride (787564-37-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

(3R)-3-Fluoropiperidine-1-carboxylic acid tert-butyl ester

(R)-1-benzyl-3-fluoro-piperidine

(S)-N-benzyl-2-fluoromethylpyrrolidine

(3R)-3-fluoro-N-tosylpiperidine

Refernces

• 1、 -. "PYRAZOLE DERIVATIVES". Page/Page column 47. . Retrieved 2010/11/26.
• 2、 -. "FIVE-MEMBERED HETEROCYCLIC DERIVATIVE". Page/Page column 59. . Retrieved 2010/11/08.