(E)-3-Bromoacrylaldehyde

Base Information

• Chemical Name: (E)-3-Bromoacrylaldehyde
• CAS No.: 71653-11-7
• Molecular Formula: C₃H₃BrO
• Molecular Weight: 134.96
• Mol file: 71653-11-7.mol

Synonyms:(E)-3-Bromoacrylaldehyde

Chemical Property of (E)-3-Bromoacrylaldehyde

Chemical Property:

• Boiling Point: 52 - 54 °C (34.5 - 35 mmHg)
• PSA: 17.07000
• LogP: 1.09390

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-3-Bromoacrylaldehyde

There total 4 articles about (E)-3-Bromoacrylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-bromoprop-2-en-1-ol (37428-55-0) → trans-β-bromoacrolein (71653-11-7)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/ejoc.201300183

Reference yield:

(E)-3-bromoacrolein diethyl acetal (86046-93-7) → trans-β-bromoacrolein (71653-11-7)

Guidance literature:

With oxalic acid; silica gel; In diethyl ether; water; for 10h; Ambient temperature;

DOI:10.1021/ja00353a027

Reference yield:

3,3-dibromo-1-chloro-1-methoxypropane (100703-87-5) → trans-β-bromoacrolein (71653-11-7)

Guidance literature:

With sodium carbonate; beim Erwaermen;

DOI:10.1002/clc.4960260205

upstream raw materials:

3,3-dibromo-1-chloro-1-methoxypropane

(E)-3-bromoacrolein diethyl acetal

water

(E)-3-bromoprop-2-en-1-ol

Downstream raw materials:

3t-bromo-acrylaldehyde-(2,4-dinitro-phenylhydrazone)

Refernces

• 1、 Kamptmann, Sonja B.,Brueckner, Reinhard. "Stereocontrolled synthesis of a Cn-Cn+7 building block ("eastern moiety") for the unnatural enantiomers of important polyol,polyene antibiotics based on a ring-closing metathesis and an aldol addition of a lactone enolate". supporting information. p. 6584 - 6600. Retrieved 2013/11/06.