1,3-Di-O-tert-butyldiMethylsilyl Paricalcitol 18-Aldehyde

Base Information

• Chemical Name: 1,3-Di-O-tert-butyldiMethylsilyl Paricalcitol 18-Aldehyde
• CAS No.: 1257126-71-8
• Molecular Formula: C₃₃H₆₀O₃Si₂
• Molecular Weight: 561.009
• Mol file: 1257126-71-8.mol

Synonyms:1,3-Di-O-tert-butyldiMethylsilyl Paricalcitol 18-Aldehyde;(αS,1R,3aS,7aR)-4-[2-[(3R,5R)-3,5-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]cyclohexylidene]ethylidene]octahydro-α,7a-diMethyl-1H-indene-1-acetaldehyde

Chemical Property of 1,3-Di-O-tert-butyldiMethylsilyl Paricalcitol 18-Aldehyde

Chemical Property:

• PSA: 35.53000
• LogP: 9.85530
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

98% ^*data from raw suppliers

1,3-Di-O-tert-butyldimethylsilylParicalcitol18-Aldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,3-Di-O-tert-butyldiMethylsilyl Paricalcitol 18-Aldehyde is used in the preparation of Paricalcitol (P195300).

Technology Process of 1,3-Di-O-tert-butyldiMethylsilyl Paricalcitol 18-Aldehyde

There total 20 articles about 1,3-Di-O-tert-butyldiMethylsilyl Paricalcitol 18-Aldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C33H62O3Si2 → C33H60O3Si2 (1257126-71-8)

Guidance literature:

With potassium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h; Reagent/catalyst; Inert atmosphere;

Reference yield: 92.0%

C33H62O3Si2 → C33H60O3Si2 (1257126-71-8)

Guidance literature:

With potassium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h; Reagent/catalyst; Inert atmosphere;

Reference yield: 89.0%

((1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((S)-1,1-dimethoxypropan-2-yl)-7a-methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)cyclohexane-1,3-diyl)bis(oxy)bis(tertbutyldimethylsilane) (957214-02-7) → (S)-2-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tertbutyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)propanal (142777-78-4,1257126-71-8)

Guidance literature:

((1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((S)-1,1-dimethoxypropan-2-yl)-7a-methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)cyclohexane-1,3-diyl)bis(oxy)bis(tertbutyldimethylsilane); With trifluoroacetic acid; In chloroform; water; at 0 ℃; for 0.416667h;

With sodium hydrogencarbonate; In chloroform; water;

upstream raw materials:

(E)-(1R,3R,20S)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-20-methyl-19-nor-9,10-seco-pregna-5,7-dien-21-ol

((1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((S)-1,1-dimethoxypropan-2-yl)-7a-methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)cyclohexane-1,3-diyl)bis(oxy)bis(tertbutyldimethylsilane)

(8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol

Acetic acid (S)-2-{(1R,3aS,7aR)-4-[2-[(3R,5R)-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl ester

Downstream raw materials:

(S)-4-Benzenesulfonyl-2-{(1R,3aS,7aR)-4-[2-[(3R,5R)-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-8-ethyl-8-triethylsilanyloxy-decan-3-ol

2-((E)-(2R,5R)-5-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-1,1,2-trimethyl-hex-3-enyloxy)-tetrahydro-furan

Refernces

• 1、 -. "Preparation method for paricalcitol". . . Retrieved 2018/04/01.
• 2、 -. "HYBRID MOLECULES HAVING MIXED VITAMIN D RECEPTOR AGONISM AND HISTONE DEACETYLASE INHIBITORY PROPERTIES". Page/Page column 24; 49-50. . Retrieved 2008/06/13.