1,4-diphenyl-2-(piperidin-1-yl)but-2-ene-1,4-dione

Base Information

• Chemical Name: 1,4-diphenyl-2-(piperidin-1-yl)but-2-ene-1,4-dione
• CAS No.: 5468-69-9
• Molecular Formula: C21H21NO2
• Molecular Weight: 319.403
• Mol file: 5468-69-9.mol

Synonyms:

Chemical Property of 1,4-diphenyl-2-(piperidin-1-yl)but-2-ene-1,4-dione

Chemical Property:

• Vapor Pressure: 1.02E-08mmHg at 25°C
• Boiling Point: 462°Cat760mmHg
• Flash Point: 193.9°C
• Density: 1.153g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-diphenyl-2-(piperidin-1-yl)but-2-ene-1,4-dione

There total 8 articles about 1,4-diphenyl-2-(piperidin-1-yl)but-2-ene-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

piperidine (110-89-4) + 2-diazo-acetophenone (3282-32-4) → (E)-1,4-diphenyl-2-(piperidin-1-yl)but-2-ene-1,4-dione (5468-69-9,66164-12-3)

Guidance literature:

With oxygen; gold; In acetonitrile; at 60 ℃; for 29h; under 760.051 Torr;

DOI:10.1007/s10562-010-0339-7

Reference yield: 83.0%

piperidine (110-89-4) + 2-(methylthio)-1,4-diphenylbut-2-ene-1,4-dione (63113-55-3,63113-56-4) → (E)-1,4-diphenyl-2-(piperidin-1-yl)but-2-ene-1,4-dione (5468-69-9,66164-12-3)

Guidance literature:

In ethanol; at 78 ℃; for 28h; diastereoselective reaction;

DOI:10.1016/j.tet.2012.03.049

Reference yield: 76.0%

piperidine (110-89-4) + phenylglyoxal hydrate (1074-12-0) + phenylacetylene (536-74-3) → (E)-1,4-diphenyl-2-(piperidin-1-yl)but-2-ene-1,4-dione (5468-69-9,66164-12-3)

Guidance literature:

With gold(III) tribromide; oxygen; In methanol; water; at 50 ℃; for 6h; stereoselective reaction;

DOI:10.3184/174751916X14579667880206

upstream raw materials:

piperidine

2,3-dibromo-1,4-diphenyl-butane-1,4-dione

1,4-diphenyl-but-2-yne-1,4-dione

phenylglyoxal hydrate

Refernces

• 1、 -. "A 2-amino-butene 1,4-dione derivative synthesis method (by machine translation)". Paragraph 0035. . Retrieved 2017/03/14.
• 2、 Deng, Cong,Yang, Yan,Gao, Meng,Zhu, Yan-Ping,Wu, An-Xin,Ma, Jun-Rui,Yin, Guo-Dong. "Substrate-controlled and highly stereoselective synthesis of 2-aminobut-2-ene-1, 4-diones". experimental part. p. 3828 - 3834. Retrieved 2012/07/02.