N-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetaMide

Base Information

• Chemical Name: N-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetaMide
• CAS No.: 1369966-94-8
• Molecular Formula: C9H12N2OS
• Molecular Weight: 196.26938
• Hs Code.: 2933399990
• Mol file: 1369966-94-8.mol

Synonyms:N-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetaMide

Chemical Property of N-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetaMide

Chemical Property:

• Boiling Point: 426.8±45.0 °C(Predicted)
• PKA: 14.80±0.20(Predicted)
• PSA: 69.37000
• Density: 1.267±0.06 g/cm3(Predicted)
• LogP: 1.75400

Purity/Quality:

97% ^*data from raw suppliers

N-(4,5,6,7-Tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetaMide

There total 6 articles about N-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-acetamido-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate (1369967-32-7) → N-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide (1369966-94-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 25 ℃; Inert atmosphere;

DOI:10.1021/jm201537d

Reference yield:

2-acetamido-6-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid (1369967-31-6) → N-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide (1369966-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl acetamide / 2 h / 170 °C / Inert atmosphere; Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 25 °C / Inert atmosphere

With trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide;

DOI:10.1021/jm201537d

Reference yield:

6-(tert-butyl) 3-ethyl 2-acetamido-4,7-dihydrothieno[2,3-c]pyridine-3,6(5H)-dicarboxylate (874801-58-8) → N-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)acetamide (1369966-94-8)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium hydroxide / tetrahydrofuran; water / 12 h / Inert atmosphere; Reflux

2: N,N-dimethyl acetamide / 2 h / 170 °C / Inert atmosphere; Microwave irradiation

3: trifluoroacetic acid / dichloromethane / 25 °C / Inert atmosphere

With trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water;

DOI:10.1021/jm201537d

upstream raw materials:

2-acetamido-6-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid

tert-butyl 2-acetamido-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate

6-(tert-butyl) 3-ethyl 2-acetamido-4,7-dihydrothieno[2,3-c]pyridine-3,6(5H)-dicarboxylate

N-tert-butyloxycarbonylpiperidin-4-one

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