2-[3-(S)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]phenyl-2-(1’-hydroxy-2’-methoxymethyl)propanol

Base Information

Chemical Name:2-[3-(S)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]phenyl-2-(1’-hydroxy-2’-methoxymethyl)propanol
CAS No.:184764-20-3
Molecular Formula:C31H32ClNO4
Molecular Weight:518.04308
Hs Code.:
Mol file:184764-20-3.mol

Synonyms:2-[3-(S)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]phenyl-2-(1’-hydroxy-2’-methoxymethyl)propanol;2-[3-(S)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]phenyl-2-(1'-hydroxy-2'-MethoxyMethyl)propanol (Mixture of DiastereoMers)

Suppliers and Price of 2-[3-(S)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]phenyl-2-(1’-hydroxy-2’-methoxymethyl)propanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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TRC
2-[3-(S)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]phenyl-2-(1’-hydroxy-2’-methoxymethyl)propanol(MixtureofDiastereomers)
2.5mg
$ 120.00

Total 3 raw suppliers

Chemical Property of 2-[3-(S)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]phenyl-2-(1’-hydroxy-2’-methoxymethyl)propanol

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:676.095°C at 760 mmHg
Flash Point:362.69°C
PSA：71.81000
Density:1.252g/cm³
LogP:6.55280
Storage Temp.:-20°C Freezer
Solubility.:Chloroform, Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

98%Min ^*data from raw suppliers

2-[3-(S)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]phenyl-2-(1’-hydroxy-2’-methoxymethyl)propanol(MixtureofDiastereomers) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-[3-(S)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]phenyl-2-(1’-hydroxy-2’-methoxymethyl)propanol

There total 2 articles about 2-[3-(S)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]phenyl-2-(1’-hydroxy-2’-methoxymethyl)propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 100045-83-8
tributyl({[(methyloxy)methyl]oxy}methyl)stannane

: 184764-13-4
[S-(E)]-1-[2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]-phenyl]-3-hydroxypropyl]phenyl]ethanone

: 184764-20-3
(S)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-2-methoxymethoxy-1-methyl-ethyl)-phenyl]-propan-1-ol

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1021/jo9615817

Reference yield:

: 181139-72-0
methyl-[(E)]-2-[3(S)-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropyl] benzoate

: 184764-20-3
(S)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-2-methoxymethoxy-1-methyl-ethyl)-phenyl]-propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) (Me₃Si)2NLi / 1.) THF, 0 deg C, 1 h, 2.) toluene, 0 deg C, 3 h

2: 32 percent / n-BuLi / tetrahydrofuran / 1 h / -78 °C

With n-butyllithium; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/jo9615817

Reference yield:

: 184764-20-3
(S)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-2-methoxymethoxy-1-methyl-ethyl)-phenyl]-propan-1-ol

: 36-Hydroxymontelukast

Guidance literature:: Multi-step reaction with 5 steps

1: iPr₂EtN / toluene; acetonitrile / 1 h / -20 °C

2: 1.) n-BuLi / 1.) THF, 0 deg C, 30 min, 2.) THF, -15 deg C, overnight

3: diethyl ether

4: PPTS / 2-methyl-propan-2-ol / 12 h / Heating

5: 1 N LiOH / ethanol / 4 h / 60 °C / other reagent

With lithium hydroxide; n-butyllithium; pyridinium p-toluenesulfonate; N-ethyl-N,N-diisopropylamine; In diethyl ether; ethanol; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo9615817