1-(4-FLUORO-BENZYL)-2-PIPERAZIN-1-YL-1H-BENZOIMIDAZOLE

Base Information

• Chemical Name: 1-(4-FLUORO-BENZYL)-2-PIPERAZIN-1-YL-1H-BENZOIMIDAZOLE
• CAS No.: 142617-98-9
• Molecular Formula: C₁₈H₁₉FN₄
• Molecular Weight: 310.374
• Hs Code.: 2933990090
• Mol file: 142617-98-9.mol

Synonyms:1-(4-FLUORO-BENZYL)-2-PIPERAZIN-1-YL-1H-BENZOIMIDAZOLE

Chemical Property of 1-(4-FLUORO-BENZYL)-2-PIPERAZIN-1-YL-1H-BENZOIMIDAZOLE

Chemical Property:

• PSA: 33.09000
• LogP: 3.02710

Purity/Quality:

98% ^*data from raw suppliers

1-[(4-Fluorophenyl)methyl]-2-(piperazin-1-yl)-1H-1,3-benzodiazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-FLUORO-BENZYL)-2-PIPERAZIN-1-YL-1H-BENZOIMIDAZOLE

There total 1 articles about 1-(4-FLUORO-BENZYL)-2-PIPERAZIN-1-YL-1H-BENZOIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4''-fluorobenzyl)-1,2-phenylenediamine (7191-70-0) → 1-(4-fluorophenylmethyl)-2-(1-piperazinyl)-1H-benzimidazole (142617-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 2 h / 60 °C

2: 1-methyl-pyrrolidin-2-one / 1 h / 180 °C / Microwave irradiation

With sodium hydride; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2017.10.004

upstream raw materials:

N-(4''-fluorobenzyl)-1,2-phenylenediamine

Refernces