8-Azabicyclo[3.2.1]octane,3-(2-methylphenyl)-(9CI)

Base Information

Chemical Name:8-Azabicyclo[3.2.1]octane,3-(2-methylphenyl)-(9CI)
CAS No.:780035-79-2
Molecular Formula:C₁₄H₁₉N
Molecular Weight:201.312
Hs Code.:
Mol file:780035-79-2.mol

Synonyms:8-Azabicyclo[3.2.1]octane,3-(2-methylphenyl)-(9CI)

Suppliers and Price of 8-Azabicyclo[3.2.1]octane,3-(2-methylphenyl)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-(2-METHYLPHENYL)-8-AZABICYCLO-[3.2.1]-OCTANE 95.00%
5MG
$ 501.46

Total 2 raw suppliers

Chemical Property of 8-Azabicyclo[3.2.1]octane,3-(2-methylphenyl)-(9CI)

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

3-(2-METHYLPHENYL)-8-AZABICYCLO-[3.2.1]-OCTANE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-Azabicyclo[3.2.1]octane,3-(2-methylphenyl)-(9CI)

There total 6 articles about 8-Azabicyclo[3.2.1]octane,3-(2-methylphenyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: C₁₉H₂₇NO₂

: 780035-79-2
3-(o-tolyl)-8-azabicyclo[3.2.1]octane

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/acsmedchemlett.6b00186

Reference yield:

: 185099-67-6
N-Boc-nortropinone

: 780035-79-2
3-(o-tolyl)-8-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 2.17 h / -78 °C

1.2: 2.83 h / -78 - 20 °C

2.1: sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 3 h / 60 °C / Inert atmosphere

3.1: hydrogen; 5%-palladium/activated carbon / ethanol / 760.05 Torr

4.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; hydrogen; sodium hexamethyldisilazane; sodium carbonate; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 2.1: |Suzuki Coupling;
DOI:10.1021/acsmedchemlett.6b00186

Reference yield:

: (8-azabicyclo[3.2.1]octan-3-one) hydrochloride

: 780035-79-2
3-(o-tolyl)-8-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water / 0 - 20 °C

2.1: triethylamine; dmap / dichloromethane / 19 h / 0 - 20 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 2.17 h / -78 °C

3.2: 2.83 h / -78 - 20 °C

4.1: sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 3 h / 60 °C / Inert atmosphere

5.1: hydrogen; 5%-palladium/activated carbon / ethanol / 760.05 Torr

6.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; hydrogen; sodium hexamethyldisilazane; sodium carbonate; triethylamine; trifluoroacetic acid; lithium chloride; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 4.1: |Suzuki Coupling;
DOI:10.1021/acsmedchemlett.6b00186